\u2013 Trong khi \u0111\u00f3, qu\u1ea7n th\u1ec3 vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t ng\u0103n c\u1ea3n t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh l\u00e0m t\u1ed5 b\u1eb1ng c\u00e1ch: <\/p>\n\n\n\n
- C\u1ea1nh tranh ch\u1ed7 b\u00e1m tr\u00ean c\u00e1c th\u1ee5 th\u1ec3 c\u1ee7a bi\u1ec3u m\u00f4 ru\u1ed9t n\u00ean s\u1ebd c\u1ea1nh tranh kh\u00f4ng gian b\u00e1m v\u00e0 sinh s\u1ed1ng trong \u0111\u01b0\u1eddng ru\u1ed9t <\/li>
- C\u1ea1nh tranh ngu\u1ed3n dinh d\u01b0\u1ee1ng c\u00f3 m\u1eb7t trong d\u01b0\u1ee1ng tr\u1ea5p <\/li>
- S\u1ea3n xu\u1ea5t c\u00e1c ch\u1ea5t kh\u00e1ng khu\u1ea9n \u0111\u1ec3 \u1ee9c ch\u1ebf s\u1ef1 sinh s\u00f4i c\u1ee7a t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh; <\/li>
- T\u1ea1o ra m\u1ed9t m\u00f4i tr\u01b0\u1eddng ch\u1ee9a nh\u1eefng ch\u1ea5t bi\u1ebfn d\u01b0\u1ee1ng kh\u00f4ng ph\u00f9 h\u1ee3p cho s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh \u0111\u01b0\u1eddng ru\u1ed9t (Lievin et al., 2000) <\/li>
- \u1ea2nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 ph\u00e2n ti\u1ebft cytokine c\u1ee7a t\u1ebf b\u00e0o ph\u00e2n ti\u1ebft \u1edf bi\u1ec3u m\u00f4 ru\u1ed9t v\u00e0 t\u1eeb \u0111\u00f3 \u0111i\u1ec1u khi\u1ec3n s\u1ef1 ch\u1ebf ti\u1ebft kh\u00e1ng th\u1ec3 c\u1ee7a lympho B. <\/li>
- S\u1ef1 b\u00e1m d\u00ednh c\u1ee7a c\u00e1c vi khu\u1ea9n c\u00f3 l\u1ee3i \u0111\u01b0\u1eddng ru\u1ed9t l\u00ean c\u00e1c th\u1ee5 th\u1ec3 tr\u00ean t\u1ebf b\u00e0o ru\u1ed9t c\u00f2n ph\u00e1t ra nh\u1eefng k\u00edch th\u00edch \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch b\u1ea9m sinh c\u0169ng nh\u01b0 mi\u1ec5n d\u1ecbch thu \u0111\u01b0\u1ee3c. Vi\u1ec7c \u0111\u00f3 gi\u00fap cho h\u1ec7 mi\u1ec5n d\u1ecbch lu\u00f4n \u1edf trong t\u00ecnh tr\u1ea1ng s\u1eb5n s\u00e0ng chi\u1ebfn \u0111\u1ea5u. <\/li>
- Vi khu\u1ea9n c\u00f3 l\u1ee3i \u0111\u01b0\u1eddng ru\u1ed9t c\u0169ng l\u00e0 m\u1ed9t y\u1ebfu t\u1ed1 k\u00edch th\u00edch ni\u00eam m\u1ea1c ru\u1ed9t ti\u1ebfn h\u00e0nh ch\u1eefa l\u00e0nh nh\u1eefng v\u1ebf th\u01b0\u01a1ng xu\u1ea5t hi\u1ec7n tr\u00ean m\u00e0ng nh\u1ea7y ru\u1ed9t (Elliot et al., 1998). <\/li>
- <\/li><\/ul>\n\n\n\n
Vai tr\u00f2 k\u00edch th\u00edch h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch thi\u1ebft l\u1eadp tr\u1ea1ng th\u00e1i \u0111\u1ec1 kh\u00e1ng<\/h4>\n\n\n\n
Ng\u01b0\u1eddi ta ph\u00e1t hi\u1ec7n ra r\u1eb1ng vi sinh v\u1eadt c\u00f3 l\u1ee3i trong \u0111\u01b0\u1eddng ru\u1ed9t, bao g\u1ed3m c\u00e1c lo\u1ea1i vi khu\u1ea9n th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c ch\u1ebf ph\u1ea9m men vi sinh s\u1ed1ng nh\u01b0 Lactobacillus, Bacillus subtilis c\u00f3 kh\u1ea3 n\u0103ng k\u00edch th\u00edch lympho B \u0111\u00e3 ho\u1ea1t h\u00f3a b\u1edfi kh\u00e1ng nguy\u00ean, tr\u1ea3i qua qu\u00e1 tr\u00ecnh chuy\u1ec3n l\u1edbp chu\u1ed7i n\u1eb7ng \u0111\u1ec3 t\u1eadp trung s\u1ea3n xu\u1ea5t kh\u00e1ng th\u1ec3 IgA \u0111\u1eb7c hi\u1ec7u, l\u00e0 lo\u1ea1i kh\u00e1ng th\u1ec3 chuy\u00ean tr\u00e1ch vi\u1ec7c trung h\u00f2a v\u00e0 b\u1eaft gi\u1eef c\u00e1c vi sinh v\u1eadt hay kh\u00e1ng nguy\u00ean xu\u1ea5t hi\u1ec7n tr\u00ean c\u00e1c m\u00e0ng nh\u00e0y trong c\u01a1 th\u1ec3. C\u01a1 ch\u1ebf c\u1ee7a hi\u1ec7n t\u01b0\u1ee3ng n\u00e0y l\u00e0 do c\u00e1c vi khu\u1ea9n n\u00e0y (Lactobacillus, Bacillus subtilis) k\u00edch th\u00edch c\u00e1c th\u1ee5 th\u1ec3 TLR tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o bi\u1ec3u m\u1ed9 ru\u1ed9t v\u00e0 t\u1ebf b\u00e0o tua, l\u00e0m c\u00e1c t\u1ebf b\u00e0o n\u00e0y ti\u1ebft ra cytokine t\u00ean l\u00e0 APRIL (a proliferation inducing ligand) v\u00e0 BAFF (tumor necrosis factor family). \u0110\u00e2y l\u00e0 hai y\u1ebfu t\u1ed1 c\u00f3 c\u1ea5u tr\u00fac g\u1ea7n gi\u1ed1ng v\u1edbi ph\u00e2n t\u1eed CD40L bi\u1ec3u hi\u1ec7n tr\u00ean b\u1ec1 m\u1eb7t lympho T gi\u00fap 2 (TH2) (xem th\u00eam v\u1ec1 lympho B v\u00e0 TH2 trong ph\u1ea7n \u2018\u0110\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch d\u1ecbch th\u1ec3\u2019). V\u00ec v\u1eady, t\u01b0\u01a1ng t\u1ef1 nh\u01b0 CD40L, hai cytokine APRIL v\u00e0 BAFF c\u0169ng l\u00e0 c\u00e1c y\u1ebfu t\u1ed1 k\u00edch th\u00edch s\u1ef1 t\u0103ng sinh v\u00e0 bi\u1ec7t h\u00f3a th\u00e0nh t\u01b0\u01a1ng b\u00e0o c\u1ee7a c\u00e1c lympho B m\u00e0 kh\u00f4ng c\u1ea7n s\u1ef1 h\u1ed7 tr\u1ee3 nh\u01b0 th\u01b0\u1eddng th\u1ea5y t\u1eeb c\u00e1c lympho TH2. Vi\u1ec7c lympho B s\u1ea3n xu\u1ea5t IgA t\u1ea5t nhi\u00ean c\u0169ng x\u1ea3y ra khi c\u00f3 s\u1ef1 k\u00edch th\u00edch t\u1eeb c\u00e1c vi sinh v\u1eadt g\u00e2y b\u1ec7nh th\u1ef1c th\u1ee5 nh\u01b0 \u0111\u00e3 \u0111\u01b0\u1ee3c quan s\u00e1t \u0111\u1ed1i v\u1edbi Salmonella typhimurium (He et al., 2007). Kh\u00eda c\u1ea1nh t\u00edch c\u1ef1c ch\u00fang ta th\u1ea5y \u0111\u01b0\u1ee3c \u1edf \u0111\u00e2y l\u00e0 vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c lo\u1ea1i vi sinh s\u1ed1ng c\u00f3 l\u1ee3i cho \u0111\u01b0\u1eddng ru\u1ed9t, kh\u00f4ng nh\u1eefng ch\u1ec9 gi\u00fap ph\u1ee5c h\u1ed3i h\u1ec7 vi sinh v\u1eadt c\u00f3 l\u1ee3i trong \u0111\u01b0\u1eddng ru\u1ed9t, nh\u01b0ng ch\u00fang c\u00f2n gi\u00fap k\u00edch th\u00edch s\u1ef1 ph\u00e2n ti\u1ebft kh\u00e1ng th\u1ec3 IgA \u0111\u1eb7c hi\u1ec7u ch\u1ed1ng l\u1ea1i c\u00e1c t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh kh\u00e1c. \u0110\u1eb7c bi\u1ec7t l\u00e0 ph\u1ea3n \u1ee9ng n\u00e0y x\u1ea3y ra m\u1ea1nh m\u1ebd nh\u1ea5t t\u1ea1i ph\u1ea7n ru\u1ed9t gi\u00e0, n\u01a1i c\u00f3 m\u1eadt \u0111\u1ed9 t\u1eadp trung cao nh\u1ea5t c\u1ee7a vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t.<\/p>\n\n\n\n
![\"\"](\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/visinhduongruot.jpg\")
<\/figure><\/div>\n\n\n\nH\u00ecnh 2 m\u00f4 t\u1ea3 c\u01a1 ch\u1ebf c\u00e1c t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 v\u00e0 c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch \u1edf m\u00e0ng nh\u1ea7y ru\u1ed9t s\u1eed d\u1ee5ng \u0111\u1ec3 ph\u00e1t hi\u1ec7n s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a c\u00e1c vi sinh v\u1eadt hi\u1ec7n di\u1ec7n trong b\u1ec1 m\u1eb7t bi\u1ec3u m\u00f4 ru\u1ed9t. \u0110\u00e2y l\u00e0 m\u1ed9t qu\u00e1 tr\u00ecnh \u0111\u00f2i h\u1ecfi s\u1ef1 t\u01b0\u01a1ng t\u00e1c, ti\u1ebfp x\u00fac l\u1eabn nhau gi\u1eefa c\u00e1c vi khu\u1ea9n, t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 ru\u1ed9t, c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch. T\u1ebf b\u00e0o bi\u1ec3u m\u00f4, t\u1ebf b\u00e0o M, t\u1ebf b\u00e0o tua c\u00f3 kh\u1ea3 n\u0103ng tr\u1ef1c ti\u1ebfp t\u01b0\u01a1ng t\u00e1c v\u1edbi vi khu\u1ea9n b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng c\u00e1c th\u1ee5 th\u1ec3 b\u1ec1 m\u1eb7t c\u1ee7a ch\u00fang l\u00e0 TLR v\u00e0 NLR. Sau \u0111\u00f3, nh\u1eefng t\u1ebf b\u00e0o n\u00e0y s\u1ebd th\u00f4ng b\u00e1o nh\u1eefng ph\u00e1t hi\u1ec7n c\u1ee7a ch\u00fang cho c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch lympho B v\u00e0 T th\u00f4ng qua c\u00e1c vi\u1ec7c ti\u1ebft ra c\u00e1c cytokines, chemokines \u0111\u1eb7c hi\u1ec7u; ho\u1eb7c tr\u1ef1c ti\u1ebfp tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean tr\u00ean MHC I, MHC II cho c\u00e1c lympho b\u00e0o.<\/p>\n\n\n\n
Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi ch\u1ee9c n\u0103ng c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch<\/h4>\n\n\n\n
\u2013 V\u1ec1 m\u1eb7t mi\u1ec5n d\u1ecbch, c\u00f3 s\u1ef1 suy gi\u1ea3m v\u1ec1 c\u1ea5u tr\u00fac, ch\u1ee9c n\u0103ng v\u00e0 ho\u1ea1t \u0111\u1ed9ng c\u1ee7a t\u1ebf b\u00e0o v\u00e0 c\u01a1 quan mi\u1ec5n d\u1ecbch khi h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t b\u1ecb m\u1ea5t ho\u1eb7c b\u1ecb t\u1ed5n th\u01b0\u01a1ng. Nh\u1eefng t\u1ed5n h\u1ea1i x\u1ea3y ra tr\u00ean h\u1ec7 mi\u1ec5n d\u1ecbch c\u00f3 th\u1ec3 k\u1ec3 \u0111\u1ebfn nh\u01b0:<\/p>\n\n\n\n
+ K\u00edch th\u01b0\u1edbc c\u1ee7a h\u1ea1ch b\u1ea1ch huy\u1ebft, l\u00e1ch v\u00e0 m\u1ea3ng Peyer \u0111\u1ec1u gi\u1ea3m<\/p>\n\n\n\n
+ C\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch khu tr\u00fa trong th\u00e0nh ru\u1ed9t (lympho b\u00e0o, t\u01b0\u01a1ng b\u00e0o, b\u1ea1ch c\u1ea7u \u0111\u01a1n nh\u00e2n\u2026) \u0111\u1ec1u gi\u1ea3m, c\u00f3 l\u1ebd do thi\u1ebfu \u0111i s\u1ef1 k\u00edch th\u00edch mi\u1ec5n d\u1ecbch c\u1ee7a c\u00e1c vi khu\u1ea9n thu\u1ed9c h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t. Khi \u0111\u00f3, l\u01b0\u1ee3ng t\u01b0\u01a1ng b\u00e0o s\u1ea3n xu\u1ea5t IgA \u1edf l\u1edbp \u0111\u1ec7m d\u01b0\u1edbi ni\u00eam m\u1ea1c ru\u1ed9t c\u0169ng gi\u1ea3m \u0111i. V\u00ec v\u1eady, t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh d\u1ec5 d\u00e0ng x\u00e2m nh\u1eadp th\u00f4ng qua ni\u00eam m\u1ea1c ru\u1ed9t.<\/p>\n\n\n\n
+ Gi\u1ea3m kh\u1ea3 n\u0103ng ho\u1ea1t h\u00f3a ph\u1ea3n \u1ee9ng vi\u00eam, gi\u1ea3m kh\u1ea3 n\u0103ng l\u00e0m l\u00e0nh v\u1ebft th\u01b0\u01a1ng<\/p>\n\n\n\n
+ Gi\u1ea3m kh\u1ea3 n\u0103ng k\u00edch ho\u1ea1t \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch \u0111\u1ed1i v\u1edbi vacxin ho\u1eb7c nhi\u1ec5m m\u1ea7m b\u1ec7nh t\u1ef1 nhi\u00ean<\/p>\n\n\n\n
+ Gi\u1ea3m l\u01b0\u1ee3ng kh\u00e1ng th\u1ec3 \u0111\u01b0\u1ee3c t\u1ea1o ra trong m\u00e1u c\u0169ng nh\u01b0 kh\u00e1ng th\u1ec3 IgA tr\u00ean ni\u00eam m\u1ea1c<\/p>\n\n\n\n
Th\u00ed nghi\u1ec7m so s\u00e1nh gi\u1eefa th\u00fa nu\u00f4i trong \u0111i\u1ec1u ki\u1ec7n b\u00ecnh th\u01b0\u1eddng v\u00e0 th\u00fa nu\u00f4i trong \u0111i\u1ec1u ki\u1ec7n kh\u00f4ng vi sinh v\u1eadt (germ-free) cho th\u1ea5y r\u1eb1ng:<\/p>\n\n\n\n
\u2013 H\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t l\u00e0 nh\u00e2n t\u1ed1 quan tr\u1ecdng ph\u1ea3i c\u00f3 \u0111\u1ec3 k\u00edch th\u00edch s\u1ef1 h\u00ecnh th\u00e0nh m\u1ea1ch m\u00e1u trong h\u1ec7 th\u1ed1ng bi\u1ec3u m\u00f4 ru\u1ed9t. Th\u00fa s\u1ed1ng trong \u0111i\u1ec1u ki\u1ec7n kh\u00f4ng vi sinh v\u1eadt (kh\u00f4ng c\u00f3 b\u1ea5t k\u1ef3 vi sinh v\u1eadt n\u00e0o s\u1ed1ng trong v\u00e0 tr\u00ean c\u01a1 th\u1ec3 th\u00fa) c\u00f3 h\u1ec7 th\u1ed1ng mao m\u1ea1ch c\u1ee7a nhung mao ru\u1ed9t kh\u00f4ng ph\u00e1t tri\u1ec3n sau cai s\u1eefa, v\u00e0 ngay c\u1ea3 khi ch\u00fang \u0111\u00e3 l\u1edbn so v\u1edbi th\u00fa nu\u00f4i b\u00ecnh th\u01b0\u1eddng.<\/p>\n\n\n\n
\u2013 H\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t gi\u00fap k\u00edch th\u00edch t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 ru\u1ed9t s\u1ea3n xu\u1ea5t c\u00e1c ch\u1ea5t ti\u1ebft c\u00f3 t\u00ednh kh\u00e1ng khu\u1ea9n, kh\u00e1ng virus.<\/p>\n\n\n\n
\u2013 H\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t c\u0169ng k\u00edch th\u00edch s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch th\u00edch \u1ee9ng \u0111\u1eb7c hi\u1ec7u. Ch\u00ednh c\u00e1c vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t k\u00edch th\u00edch s\u1ef1 t\u0103ng sinh, tr\u01b0\u1edfng th\u00e0nh v\u00e0 ho\u1ea1t h\u00f3a c\u00e1c lympho B trong m\u1ea3ng Peyer v\u00e0 gi\u00fap c\u00e1c t\u01b0\u01a1ng b\u00e0o chuy\u1ec3n l\u1edbp chu\u1ed7i n\u1eb7ng \u0111\u1ec3 s\u1ea3n xu\u1ea5t kh\u00e1ng th\u1ec3 IgA ti\u1ebft ra l\u1edbp m\u00e0ng nh\u1ea7y trong \u0111\u01b0\u1eddng ru\u1ed9t. Th\u00fa s\u1ed1ng trong \u0111i\u1ec1u ki\u1ec7n kh\u00f4ng vi sinh v\u1eadt s\u1ea3n xu\u1ea5t r\u1ea5t \u00edt IgA c\u0169ng nh\u01b0 r\u1ea5t \u00edt lympho B v\u00e0 T tu\u1ea7n ho\u00e0n trong m\u00e1u. T\u01b0\u01a1ng t\u1ef1 nh\u01b0 v\u1eady, l\u01b0\u1ee3ng lympho T, t\u1ebf b\u00e0o NK hi\u1ec7n di\u1ec7n trong c\u00e1c l\u1edbp bi\u1ec3u m\u00f4 c\u0169ng th\u1ea5p h\u01a1n kho\u1ea3ng 10 l\u1ea7n so v\u1edbi th\u00fa nu\u00f4i trong \u0111i\u1ec1u ki\u1ec7n b\u00ecnh th\u01b0\u1eddng. C\u0169ng quan tr\u1ecdng kh\u00f4ng k\u00e9m l\u00e0 kh\u1ea3 n\u0103ng ph\u1ea3n \u1ee9ng c\u1ee7a lympho b\u00e0o, lympho Tc c\u1ee7a th\u00fa nu\u00f4i trong \u0111i\u1ec1u ki\u1ec7n kh\u00f4ng vi sinh v\u1eadt ph\u1ea3n \u1ee9ng r\u1ea5t k\u00e9m, kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng gi\u1ebft t\u1ebf b\u00e0o \u0111\u00edch so v\u1edbi lympho Tc c\u1ee7a th\u00fa nu\u00f4i b\u00ecnh th\u01b0\u1eddng.<\/p>\n\n\n\n
![\"\"](\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/visinhduongruot-2-291x300.jpg\")
<\/figure><\/div>\n\n\n\nNh\u1eefng quan s\u00e1t n\u00e0y c\u0169ng t\u01b0\u01a1ng \u0111\u1ed3ng v\u1edbi nh\u1eefng quan s\u00e1t trong c\u00e1c th\u00ed nghi\u1ec7m tr\u00ean chu\u1ed9t (Yoshiya et al., 2011). H\u00ecnh 4 cho th\u1ea5y khi h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t c\u1ee7a chu\u1ed9t b\u1ecb gi\u1ebft b\u1edfi kh\u00e1ng sinh th\u00ec kh\u1ea3 n\u0103ng g\u00e2y vi\u00eam v\u00e0 l\u00e0m l\u00e0nh v\u1ebft th\u01b0\u01a1ng gi\u1ea3m. C\u1ee5 th\u1ec3 l\u00e0 r\u1ea5t \u00edt b\u1ed5 th\u1ec3 \u0111\u01b0\u1ee3c huy \u0111\u1ed9ng \u0111\u1ebfn v\u00f9ng m\u00f4 b\u1ecb t\u1ed5n th\u01b0\u01a1ng (v\u1ecb tr\u00ed c\u00e1c m\u0169i t\u00ean trong H\u00ecnh D). Trong khi \u0111\u00f3, \u1edf chu\u1ed9t kh\u1ecfe m\u1ea1nh c\u1ee7a l\u00f4 \u0111\u1ed1i ch\u1ee9ng, r\u1ea5t nhi\u1ec1u b\u1ed5 th\u1ec3 \u0111\u01b0\u1ee3c huy \u0111\u1ed9ng \u0111\u1ebfn v\u00f9ng m\u00f4 t\u1ed5n th\u01b0\u01a1ng \u0111\u1ec3 k\u00edch ho\u1ea1t qu\u00e1 tr\u00ecnh g\u00e2y vi\u00eam v\u00e0 l\u00e0m l\u00e0nh v\u1ebft th\u01b0\u01a1ng (m\u0169i t\u00ean trong H\u00ecnh B). Sham: m\u1eabu v\u1eadt \u0111\u1ed1i ch\u1ee9ng, chu\u1ed9t kh\u00f4ng b\u1ecb g\u00e2y t\u1ed5n th\u01b0\u01a1ng. MI\/R (mesenteric ischemia reperfusion): chu\u1ed9t b\u1ecb g\u00e2y \u201ct\u1ed5n th\u01b0\u01a1ng thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 \u2013 t\u00e1i t\u01b0\u1edbi m\u00e1u\u201d t\u1ea1i v\u00f9ng m\u00e0ng treo ru\u1ed9t (Yoshiya et al., 2011). B\u1ed5 th\u1ec3 trong h\u00ecnh \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng kh\u00e1ng th\u1ec3 \u0111\u1eb7c hi\u1ec7u cho m\u1ea3nh b\u1ed5 th\u1ec3 C3 b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p h\u00f3a m\u00f4 mi\u1ec5n d\u1ecbch (Immunohistochemistry, IHC).<\/p>\n\n\n\n
\u1ea2nh h\u01b0\u1edfng c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ebfn s\u1ef1 h\u00ecnh th\u00e0nh m\u1ed9t s\u1ed1 b\u1ec7nh thu\u1ed9c h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch<\/h4>\n\n\n\n
Kh\u00eda c\u1ea1nh n\u00e0y ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u tr\u00ean th\u00fa. Tuy nhi\u00ean, d\u1ef1a tr\u00ean s\u1ef1 t\u01b0\u01a1ng \u0111\u1ed3ng v\u1ec1 mi\u1ec5n d\u1ecbch h\u1ecdc v\u00e0 vi sinh h\u1ecdc, ch\u00fang ta c\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n r\u1eb1ng \u0111i\u1ec1u n\u00e0y c\u0169ng x\u1ea3y ra tr\u00ean th\u00fa nh\u01b0ng m\u1ee9c \u0111\u1ed9 \u1ea3nh h\u01b0\u1edfng v\u00e0 h\u1eadu qu\u1ea3 c\u1ee7a n\u00f3 nh\u01b0 th\u1ebf n\u00e0o th\u00ec c\u1ea7n c\u00f3 nh\u1eefng nghi\u00ean c\u1ee9u c\u1ee5 th\u1ec3 h\u01a1n.<\/p>\n\n\n\n
Tr\u00ean ng\u01b0\u1eddi, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u nh\u1eadn th\u1ea5y r\u1eb1ng nh\u1eefng thay \u0111\u1ed5i trong h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t c\u00f3 \u1ea3nh h\u01b0\u1edfng r\u00f5 r\u1ec7t \u0111\u1ed1i v\u1edbi c\u00e1c b\u1ec7nh t\u1eadt nh\u01b0 d\u1ecb \u1ee9ng, ti\u1ec3u \u0111\u01b0\u1eddng v\u00e0 b\u00e9o ph\u00ec. Nh\u1eefng tr\u1ebb em hay b\u1ecb d\u1ecb \u1ee9ng th\u01b0\u1eddng c\u00f3 s\u1ed1 lo\u1ea1i v\u00e0 s\u1ed1 l\u01b0\u1ee3ng c\u1ee7a c\u00e1c lo\u1ea1i Bifidobacterium tr\u1ebb em \u00edt h\u01a1n b\u00ecnh th\u01b0\u1eddng nh\u01b0ng l\u1ea1i c\u00f3 c\u00e1c lo\u1ea1i Bifidobacterium th\u01b0\u1eddng th\u1ea5y \u1edf ng\u01b0\u1eddi l\u1edbn nh\u01b0 B. adolescentis nhi\u1ec1u h\u01a1n b\u00ecnh th\u01b0\u1eddng. Ng\u01b0\u1eddi ta v\u1eabn ch\u01b0a x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c r\u1eb1ng s\u1ef1 thay \u0111\u1ed5i c\u1ee7a Bifidobacterium c\u00f3 th\u1ec3 l\u00e0 nguy\u00ean nh\u00e2n c\u1ee7a nhi\u1ec1u lo\u1ea1i b\u1ec7nh d\u1ecb \u1ee9ng kh\u00e1c nhau hay kh\u00f4ng; hay b\u1ec7nh d\u1ecb \u1ee9ng m\u1edbi l\u00e0 nguy\u00ean nh\u00e2n d\u1eabn \u0111\u1ebfn s\u1ef1 thay \u0111\u1ed5i c\u1ee7a c\u00e1c lo\u1ea1i vi khu\u1ea9n n\u00e0y. Tuy v\u1eady, Kalliomaki v\u00e0 c\u1ed9ng s\u1ef1 \u0111\u00e3 b\u00e1o c\u00e1o r\u1eb1ng t\u1ec9 l\u1ec7 Bifidobacterium gi\u1ea3m so v\u1edbi Clostridium trong \u0111\u01b0\u1eddng ru\u1ed9t tr\u1ebb s\u01a1 sinh l\u00e0 ti\u1ec1n \u0111\u1ec1 cho s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a lo\u1ea1i d\u1ecb \u1ee9ng do kh\u00e1ng th\u1ec3 IgE ph\u1ee5 tr\u00e1ch (d\u1ecb \u1ee9ng lo\u1ea1i 1)\u00a0(Kalliomaki et al., 2001a). B\u00ean c\u1ea1nh \u0111\u00f3, th\u00ed nghi\u1ec7m khoa h\u1ecdc c\u0169ng ch\u1ee9ng minh r\u1eb1ng cung c\u1ea5p probiotic v\u00e0 prebiotic (galacto-oligosaccharides) cho m\u1eb9 l\u00fac mang thai c\u00f3 \u1ea3nh h\u01b0\u1edfng c\u00f3 l\u1ee3i \u0111\u1ed1i v\u1edbi h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t c\u1ee7a tr\u1ebb s\u01a1 sinh v\u00e0 l\u00e0m gi\u1ea3m nguy c\u01a1 m\u1eafc b\u1ec7nh ch\u00e0m (eczema)\u00a0(Kalliomaki et al., 2001b;\u00a0Kukkonen et al., 2007) <\/p>\n\n\n\n
Bi\u00ean so\u1ea1n: TS. BSTY. \u0110inh Xu\u00e2n Ph\u00e1t<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"
H\u1ec7 vi sinh c\u00f3 l\u1ee3i \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ea1i di\u1ec7n cho m\u1ed9t h\u1ec7 sinh th\u00e1i c\u00f3 ch\u1ecdn l\u1ecdc, \u0111\u00e3 v\u00e0 \u0111ang c\u00f9ng ti\u1ebfn h\u00f3a v\u1edbi v\u1eadt ch\u1ee7. B\u00ean c\u1ea1nh c\u00e1c th\u00e0nh ph\u1ea7n c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch b\u1ea9m sinh do c\u01a1 th\u1ec3 ch\u1ebf ti\u1ebft ho\u1eb7c s\u1ea3n xu\u1ea5t , h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t cung c\u1ea5p th\u00eam m\u1ed9t l\u1edbp ph\u00f2ng ng\u1ef1 n\u1eefa trong m\u00f4i tr\u01b0\u1eddng \u0111\u00f4ng \u0111\u00fac vi sinh v\u1eadt nh\u1ea5t c\u1ee7a c\u01a1 th\u1ec3. <\/p>\n","protected":false},"author":4,"featured_media":8023,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"footnotes":""},"categories":[3,2],"tags":[],"class_list":["post-8022","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-chan-nuoi","category-sinh-hoc"],"yoast_head":"\n
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