![\"\"](\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/image001-2.jpg\")
<\/figure><\/div>\n\n\n\nTh\u1ee9 nh\u1ea5t, do s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch, v\u00ec m\u1ed9t s\u1ed1 kh\u00eda c\u1ea1nh c\u1ee7a \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch b\u1ea9m sinh c\u0169ng nh\u01b0 \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch th\u00edch \u1ee9ng ch\u01b0a ho\u00e0n to\u00e0n ph\u00e1t tri\u1ec3n khi m\u1edbi sinh m\u00e0 s\u1ebd ph\u00e1t tri\u1ec3n \u0111\u1ea7y \u0111\u1ee7 khi th\u00fa l\u1edbn d\u1ea7n.<\/p>\n\n\n\n
Th\u1ee9 hai, l\u00e0 do kinh nghi\u1ec7m ti\u1ebfp x\u00fac v\u1edbi kh\u00e1ng nguy\u00ean l\u1ea1; cho \u0111\u1ebfn khi sinh ra, m\u1ee9c \u0111\u1ed9 ti\u1ebfp x\u00fac v\u1edbi kh\u00e1ng nguy\u00ean l\u1ea1 c\u1ee7a th\u00fa con l\u00e0 c\u1ef1c k\u1ef3 th\u1ea5p.<\/p>\n\n\n\n
Th\u1ee9 ba, h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch c\u1ee7a th\u00fa con trong th\u1eddi k\u1ef3 b\u00e0o thai b\u1ecb \u1ee9c ch\u1ebf t\u1ef1 nhi\u00ean nh\u1eb1m gi\u1ea3m s\u1ea3n xu\u1ea5t c\u00e1c cytokine c\u00f3 t\u00ednh k\u00edch vi\u00eam \u0111\u1ec3 tr\u00e1nh nh\u1eefng ph\u1ea3n \u1ee9ng ti\u00eau c\u1ef1c gi\u1eefa th\u00fa m\u1eb9 v\u00e0 con trong th\u1eddi k\u1ef3 mang thai.<\/p>\n\n\n\n
V\u1ec1 m\u1eb7t c\u01a1 th\u1ec3 h\u1ecdc v\u00e0 sinh l\u00fd h\u1ecdc, bi\u1ec3u m\u00f4 \u0111\u01b0\u1eddng ti\u00eau h\u00f3a c\u0169ng nh\u01b0 \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p \u1edf th\u00fa s\u01a1 sinh \u0111\u1ec1u c\u00f3 t\u00ednh th\u1ea5m cao h\u01a1n nhi\u1ec1u so v\u1edbi th\u00fa tr\u01b0\u1edfng th\u00e0nh, ch\u1ee9ng t\u1ecf r\u1eb1ng s\u1ef1 to\u00e0n v\u1eb9n c\u1ee7a c\u00e1c c\u01a1 quan ch\u01b0a \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp. S\u1ef1 ph\u00e2n ti\u1ebft c\u00e1c c\u00f4ng c\u1ee5 b\u1ea3o v\u1ec7 h\u00f3a h\u1ecdc nh\u01b0 c\u00e1c enzyme ph\u00e2n gi\u1ea3i protein (protease) v\u00e0 c\u00e1c peptid kh\u00e1ng khu\u1ea9n c\u0169ng ch\u01b0a nhi\u1ec1u . Th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc v\u00e0 c\u1ea5u tr\u00fac c\u1ee7a l\u1edbp m\u00e0ng nh\u1ea7y, h\u00e0ng r\u00e0o b\u1eaft gi\u1eef v\u00e0 ng\u0103n ch\u1eb7n vi sinh v\u1eadt x\u00e2m nh\u1eadp, c\u0169ng ch\u01b0a \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n <\/p>\n\n\n\n
3.1. Mi\u1ec5n d\u1ecbch b\u1ea9m sinh v\u00e0 mi\u1ec5n d\u1ecbch qua trung gian t\u1ebf b\u00e0o<\/strong><\/h4>\n\n\n\nV\u1ec1 m\u1eb7t mi\u1ec5n d\u1ecbch h\u1ecdc, so v\u1edbi c\u00e1 th\u1ec3 tr\u01b0\u1edfng th\u00e0nh, tr\u1ebb hay th\u00fa s\u01a1 sinh c\u00f3 s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u c\u00f3 h\u1ea1t (b\u1ea1ch c\u1ea7u trung t\u00ednh, b\u1ea1ch c\u1ea7u \u00e1i toan, b\u1ea1ch c\u1ea7u \u00e1i ki\u1ec1m) th\u1ea5p h\u01a1n. Ngo\u00e0i ra, L-selectin l\u00e0 c\u00e1c ph\u00e2n t\u1eed b\u00e1m d\u00ednh c\u1ee7a b\u1ea1ch c\u1ea7u, c\u00f3 vai tr\u00f2 quan tr\u1ecdng trong s\u1ef1 di chuy\u1ec3n v\u00e0 tho\u00e1t m\u1ea1ch c\u1ee7a ch\u00fang (xem th\u00eam trong ph\u1ea7n \u2018B\u1ea1ch c\u1ea7u tho\u00e1t m\u1ea1ch\u2019 v\u00e0 ph\u1ea7n \u2018H\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch b\u1ea9m sinh\u2019). B\u1ea1ch c\u1ea7u c\u00f3 h\u1ea1t \u1edf th\u00fa s\u01a1 sinh l\u1ea1i bi\u1ec3u hi\u1ec7n \u00edt ph\u00e2n t\u1eed L-selectin tr\u00ean b\u1ec1 m\u1eb7t, v\u00ec th\u1ebf ch\u00fang \u00edt c\u00f3 kh\u1ea3 n\u0103ng \u0111\u00e1p \u1ee9ng l\u1ea1i c\u00e1c t\u00edn hi\u1ec7u h\u00f3a h\u01b0\u1edbng \u0111\u1ed9ng v\u00e0 tho\u00e1t m\u1ea1ch k\u00e9m (H\u00ecnh).<\/p>\n\n\n\n
![\"\"](\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/image002-259x300.jpg\")
<\/figure><\/div>\n\n\n\nH\u00ecnh \u2018T\u01b0\u01a1ng t\u00e1c gi\u1eefa c\u00e1c t\u1ebf b\u00e0o\u2019 cho th\u1ea5y lympho T ho\u1ea1t h\u00f3a d\u00f9ng ph\u00e2n t\u1eed b\u1ec1 m\u1eb7t PSGL1 ho\u1eb7c E-selectin ligand \u0111\u1ec3 ti\u1ebfp x\u00fac v\u1edbi ph\u00e2n t\u1eed P-selectin ho\u1eb7c E-selectin bi\u1ec3u hi\u1ec7n tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 t\u1ea1i v\u00f9ng vi\u00eam. Trong m\u00f4 vi\u00eam m\u00e3n t\u00ednh, th\u00ec ngo\u00e0i P-selectin v\u00e0 E-selectin, t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 c\u00f2n bi\u1ec3u hi\u1ec7n th\u00eam ph\u00e2n t\u1eed b\u1ec1 m\u1eb7t PNAD c\u00f3 kh\u1ea3 n\u0103ng ti\u1ebfp x\u00fac v\u1edbi ph\u00e2n t\u1eed L-selectin bi\u1ec3u hi\u1ec7n tr\u00ean lympho T ng\u00e2y th\u01a1. Trong khi \u0111\u00f3, khi c\u00e1c b\u1ea1ch c\u1ea7u trung t\u00ednh, b\u1ea1ch c\u1ea7u \u0111\u01a1n nh\u00e2n hay c\u00e1c h\u1ea1t do b\u1ea1ch c\u1ea7u \u0111\u01a1n nh\u00e2n v\u00e0 ti\u1ec3u c\u1ea7u ti\u1ebft ra \u0111\u00e3 ti\u1ebfp x\u00fac v\u00e0 chi\u1ebfm \u0111\u00f3ng tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 t\u1ea1i c\u00e1c m\u00f4 vi\u00eam, th\u00ec ch\u00fang s\u1ebd bi\u1ec3u hi\u1ec7n ph\u00e2n t\u1eed PSGL1 \u0111\u1ec3 t\u1ea1o ra ch\u1ed7 b\u00e1m cho c\u00e1c lympho T ng\u00e2y th\u01a1, lympho T ho\u1ea1t h\u00f3a ho\u1eb7c lympho T nh\u1edb.<\/p>\n\n\n\n
H\u01a1n n\u1eefa, c\u00e1c t\u1ebf b\u00e0o tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean (APC, g\u1ed3m t\u1ebf b\u00e0o tua, \u0111\u1ea1i th\u1ef1c b\u00e0o, lympho B; xem th\u00eam trong ph\u1ea7n \u2018C\u00e1c t\u1ebf b\u00e0o tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean\u2019) c\u1ee7a th\u00fa non c\u0169ng ho\u1ea1t \u0111\u1ed9ng v\u00e0 ph\u00e2n ti\u1ebft cytokine k\u00e9m h\u01a1n. L\u00fd do l\u00e0 v\u00ec ch\u00fang bi\u1ec3u hi\u1ec7n v\u1edbi s\u1ed1 l\u01b0\u1ee3ng th\u1ea5p \u0111\u1ed1i v\u1edbi c\u00e1c th\u1ee5 th\u1ec3 v\u00e0 ph\u00e2n t\u1eed b\u1ec1 m\u1eb7t quan tr\u1ecdng nh\u01b0 MHC I, MHC II, th\u1ee5 th\u1ec3 \u0111\u1ed3ng ho\u1ea1t h\u00f3a B7; \u0111\u1ed3ng th\u1eddi ho\u1ea1t t\u00ednh th\u1ef1c b\u00e0o (phagocytosis), nh\u1eadp b\u00e0o (endocytosis) v\u00e0 h\u00f3a h\u01b0\u1edbng \u0111\u1ed9ng (chemotaxis) c\u1ee7a ch\u00fang c\u0169ng ch\u01b0a m\u1ea1nh. B\u00ean c\u1ea1nh \u0111\u00f3, ho\u1ea1t \u0111\u1ed9ng t\u1ea7m so\u00e1t v\u00e0 ti\u00eau di\u1ec7t t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh, t\u1ebf b\u00e0o b\u1ecb nhi\u1ec5m, t\u1ebf b\u00e0o bi\u1ebfn th\u00e1i\u00a0 c\u1ee7a c\u1edf th\u1ec3 do t\u1ebf b\u00e0o NK ph\u1ee5 tr\u00e1ch c\u0169ng c\u00f2n y\u1ebfu tr\u00ean \u0111\u1ed9ng v\u1eadt s\u01a1 sinh. \u0110\u1ec3 hi\u1ec3u r\u00f5 th\u00eam v\u1ec1 ch\u1ee9c n\u0103ng c\u1ee7a t\u1ebf b\u00e0o gi\u1ebft t\u1ef1 nhi\u00ean NK, xin tham kh\u1ea3o ph\u1ea7n \u2018T\u1ebf b\u00e0o gi\u1ebft t\u1ef1 nhi\u00ean\u2019.<\/p>\n\n\n\n
\u0110\u00e1p \u1ee9ng c\u1ee7a lympho T v\u1edbi kh\u00e1ng nguy\u00ean \u1edf \u0111\u1ed9ng v\u1eadt s\u01a1 sinh y\u1ebfu h\u01a1n \u1edf \u0111\u1ed9ng v\u1eadt tr\u01b0\u1edfng th\u00e0nh, th\u1ec3 hi\u1ec7n th\u00f4ng qua m\u1ee9c s\u1ea3n xu\u1ea5t IFN\u03b3 th\u1ea5p, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch qua trung gian t\u1ebf b\u00e0o li\u00ean quan \u0111\u1ebfn lympho CD4 TH<\/sub>1 v\u00e0 CD8 T (lympho CD8 T sau khi ho\u1ea1t h\u00f3a c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 CTL hay Tc). B\u1edfi v\u1eady, n\u00f3i chung l\u00e0 tr\u00ean \u0111\u1ed9ng v\u1eadt s\u01a1 sinh, \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch th\u00edch \u1ee9ng \u0111\u1eb7c hi\u1ec7u x\u1ea3y ra m\u1ea1nh h\u01a1n \u1edf ph\u1ea7n mi\u1ec5n d\u1ecbch d\u1ecbch th\u1ec3 do lympho B ph\u1ee5 tr\u00e1ch v\u1edbi s\u1ef1 h\u1ed7 tr\u1ee3 c\u1ee7a TH<\/sub>2. M\u1eb7c d\u00f9 m\u1ed9t s\u1ed1 kh\u00e1ng nguy\u00ean vacxin m\u1ea1nh c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t c\u1ea3 ph\u1ea7n mi\u1ec5n d\u1ecbch qua trung gian t\u1ebf b\u00e0o do lympho CD8 T v\u00e0 CD4 TDTH<\/sub> (lympho T qu\u00e1 m\u1eabn mu\u1ed9n) ph\u1ee5 tr\u00e1ch v\u1edbi s\u1ef1 h\u1ed7 tr\u1ee3 c\u1ee7a CD4 TH<\/sub>1, nh\u01b0ng h\u1ea7u h\u1ebft c\u00e1c vacxin trung b\u00ecnh \u0111\u1ec1u ch\u1ee7 y\u1ebfu k\u00edch th\u00edch mi\u1ec5n d\u1ecbch d\u1ecbch th\u1ec3.<\/p>\n\n\n\n\u0110\u1ec3 hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 hai ph\u1ea7n c\u1ee7a \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch th\u00edch \u1ee9ng \u0111\u1eb7c hi\u1ec7u, xin tham kh\u1ea3o ph\u1ea7n \u2018\u0110\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch d\u1ecbch th\u1ec3\u2019 v\u00e0 \u2018\u0110\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch qua trung gian t\u1ebf b\u00e0o\u2019. H\u01a1n n\u1eefa, l\u01b0\u1ee3ng lympho T c\u00f3 ch\u1ee9c n\u0103ng \u1ee9c ch\u1ebf \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch (g\u1ecdi l\u00e0 Treg) l\u1ea1i hi\u1ec7n di\u1ec7n v\u1edbi s\u1ed1 l\u01b0\u1ee3ng l\u1edbn h\u01a1n tr\u00ean \u0111\u1ed9ng v\u1eadt s\u01a1 sinh.<\/p>\n\n\n\n
T\u00f3m l\u1ea1i, c\u00e1c t\u1ebf b\u00e0o hay c\u00e1c ch\u1ea5t tham gia \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch b\u1ea9m sinh c\u0169ng nh\u01b0 th\u00edch \u1ee9ng \u0111\u1ec1u c\u00f2n \u0111ang \u1edf trong tr\u1ea1ng th\u00e1i ph\u00e1t tri\u1ec3n, ch\u01b0a ho\u00e0n thi\u1ec7n tr\u00ean \u0111\u1ed9ng v\u1eadt s\u01a1 sinh. \u0110\u1eb7c tr\u01b0ng c\u1ee7a c\u00e1c th\u00e0nh ph\u1ea7n c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch l\u00e0 ch\u00fang c\u00f3 m\u1ed9i quan h\u1ec7 b\u1ed5 tr\u1ee3 l\u1eabn nhau. V\u00ec v\u1eady, ng\u01b0\u1eddi ta gi\u1ea3i th\u00edch r\u1eb1ng \u0111\u00e1p \u1ee9ng y\u1ebfu k\u00e9m c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch tr\u00ean th\u00fa s\u01a1 sinh m\u1ed9t ph\u1ea7n ch\u00ednh l\u00e0 do thi\u1ebfu v\u1eafng s\u1ef1 h\u1ed7 tr\u1ee3 l\u1eabn nhau n\u00e0y.<\/p>\n\n\n\n
3.2. Mi\u1ec5n d\u1ecbch th\u1ec3 d\u1ecbch<\/strong><\/h4>\n\n\n\nS\u1ed1 l\u01b0\u1ee3ng lympho B tr\u00ean \u0111\u1ed9ng v\u1eadt s\u01a1 sinh l\u00e0 r\u1ea5t cao, nh\u01b0ng kh\u1ea3 n\u0103ng tr\u01b0\u1edfng th\u00e0nh, bi\u1ec7t h\u00f3a v\u00e0 chuy\u1ec3n l\u1edbp chu\u1ed7i n\u1eb7ng c\u1ee7a ch\u00fang c\u00f2n h\u1ea1n ch\u1ebf. Qu\u00e1 tr\u00ecnh bi\u1ec7t h\u00f3a x\u1ea3y ra l\u00e0 \u0111\u1ec3 bi\u1ebfn \u0111\u1ed5i lympho B th\u00e0nh t\u01b0\u01a1ng b\u00e0o (plasma cell) chuy\u00ean s\u1ea3n xu\u1ea5t kh\u00e1ng th\u1ec3, bao g\u1ed3m m\u1ed9t trong n\u0103m lo\u1ea1i IgA, IgM, IgG, IgD v\u00e0 IgE. Ban \u0111\u1ea7u, t\u1ea5t c\u1ea3 m\u1ecdi lympho B tr\u01b0\u1edfng th\u00e0nh \u0111\u1ec1u s\u1ea3n xu\u1ea5t IgM v\u00e0 IgD \u1edf d\u1ea1ng g\u1eafn tr\u00ean b\u1ec1 m\u1eb7t (H\u00ecnh \u2018Qu\u00e1 tr\u00ecnh tr\u01b0\u1edfng th\u00e0nh v\u00e0 bi\u1ec7t h\u00f3a lympho B\u2019, giai \u0111o\u1ea1n Lympho B tr\u01b0\u1edfng th\u00e0nh). Sau \u0111\u00f3, nh\u1edd qu\u00e1 tr\u00ecnh chuy\u1ec3n l\u1edbp chu\u1ed7i n\u1eb7ng, d\u01b0\u1edbi s\u1ef1 k\u00edch th\u00edch c\u1ee7a c\u00e1c cytokine v\u00e0 \u0111\u1eb7c bi\u1ec7t l\u00e0 cytokine c\u1ee7a lympho TH<\/sub>2 m\u00e0 ch\u00fang c\u00f3 th\u1ec3 bi\u1ec7t h\u00f3a th\u00e0nh c\u00e1c t\u01b0\u01a1ng b\u00e0o s\u1ea3n xu\u1ea5t c\u00e1c lo\u1ea1i kh\u00e1ng th\u1ec3 d\u1ea1ng ti\u1ebft (secreted immunoglobulin, sIg) g\u1ed3m sIgA, sIgM, IgG v\u00e0 IgE.<\/p>\n\n\n\nSong song v\u1edbi qu\u00e1 tr\u00ecnh bi\u1ec7t h\u00f3a th\u00e0nh t\u01b0\u01a1ng b\u00e0o, m\u1ed9t s\u1ed1 lympho B ph\u00e1t tri\u1ec3n th\u00e0nh t\u1eadp h\u1ee3p c\u00e1c lympho B nh\u1edb. C\u00e1c lympho B nh\u1edb n\u00e0y c\u00f3 kh\u1ea3 n\u0103ng nh\u1eadn di\u1ec7n kh\u00e1ng nguy\u00ean \u0111\u1eb7c hi\u1ec7u \u1edf l\u1ea7n ti\u1ebfp x\u00fac ti\u1ebfp theo v\u00e0 k\u00edch ho\u1ea1t \u0111\u00e1p \u1ee9ng s\u1ea3n xu\u1ea5t kh\u00e1ng th\u1ec3 \u0111\u1eb7c hi\u1ec7u m\u1ed9t c\u00e1ch nhanh ch\u00f3ng v\u00e0 m\u1ea1nh m\u1ebd h\u01a1n so v\u1edbi l\u1ea7n ti\u1ebfp x\u00fac \u0111\u1ea7u ti\u00ean. T\u1eadp h\u1ee3p lympho B nh\u1edb bao g\u1ed3m nhi\u1ec1u lo\u1ea1i t\u1ebf b\u00e0o B nh\u1edb kh\u00e1c nhau, m\u1ed7i lo\u1ea1i mang tr\u00ean b\u1ec1 m\u1eb7t c\u1ee7a n\u00f3 duy nh\u1ea5t m\u1ed9t lo\u1ea1i kh\u00e1ng th\u1ec3 b\u1ec1 m\u1eb7t (c\u00f2n g\u1ecdi l\u00e0 th\u1ee5 th\u1ec3 BCR) kh\u00e1c nhau (g\u1ed3m IgM, IgG, IgA, IgE) t\u01b0\u01a1ng \u1ee9ng v\u1edbi m\u1ed7i lo\u1ea1i kh\u00e1ng th\u1ec3 \u0111\u1eb7c hi\u1ec7u d\u1ea1ng ti\u1ebft m\u00e0 ch\u00fang s\u1ebd s\u1ea3n xu\u1ea5t ra khi b\u1ecb k\u00edch th\u00edch. Kh\u00e1ng th\u1ec3 IgD ch\u1ec9 c\u00f3 \u1edf d\u1ea1ng b\u00e1m tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o lympho B \u1edf giai \u0111o\u1ea1n lympho B tr\u01b0\u1edfng th\u00e0nh, n\u00f3 kh\u00f4ng \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t \u1edf d\u1ea1ng ti\u1ebft v\u00e0 cho \u0111\u1ebfn nay ng\u01b0\u1eddi ta v\u1eabn chia hi\u1ec3u bi\u1ebft nhi\u1ec1u v\u1ec1 vai tr\u00f2 c\u1ee7a IgD trong \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch. \u0110\u1ec3 hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 c\u00e1c lo\u1ea1i kh\u00e1ng th\u1ec3, xin tham kh\u1ea3o ph\u1ea7n \u2018Kh\u00e1ng th\u1ec3\u2019.<\/p>\n\n\n\n
![\"\"](\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/image001-3-768x560.jpg\")
<\/figure><\/div>\n\n\n\nTr\u00ean \u0111\u1ed9ng v\u1eadt s\u01a1 sinh, ngo\u00e0i kh\u00e1ng th\u1ec3 IgG nh\u1eadn \u0111\u01b0\u1ee3c t\u1eeb m\u1eb9 th\u00f4ng qua nhau thai, qua s\u1eefa \u0111\u1ea7u v\u00e0 s\u1eefa, c\u00e1c kh\u00e1ng th\u1ec3 t\u1ef1 th\u00e2n s\u1ea3n xu\u1ea5t ra r\u1ea5t th\u1ea5p. IgA h\u1ea7u nh\u01b0 kh\u00f4ng c\u00f3. IgM r\u1ea5t th\u1ea5p m\u1eb7c d\u00f9 n\u00f3 s\u1ebd t\u0103ng nhanh ch\u00f3ng sau khi c\u00f3 s\u1ef1 k\u00edch th\u00edch c\u1ee7a kh\u00e1ng nguy\u00ean \u0111\u1ed1i v\u1edbi lympho B. M\u1ee9c \u0111\u1ed9 c\u1ee7a IgE c\u0169ng r\u1ea5t th\u1ea5p v\u00ec vi\u1ec7c s\u1ea3n xu\u1ea5t IgE \u0111\u00f2i h\u1ecfi ph\u1ea3i c\u00f3 s\u1ef1 h\u1ed7 tr\u1ee3 c\u1ee7a IL4 t\u1eeb lympho TH<\/sub>2, m\u00e0 lympho TH<\/sub>2 ch\u01b0a ho\u1ea1t \u0111\u1ed9ng m\u1ea1nh \u1edf tu\u1ed5i s\u01a1 sinh. \u0110i\u1ec1u n\u00e0y m\u1ed9t l\u1ea7n n\u1eefa cho th\u1ea5y t\u1ea7m quan tr\u1ecdng c\u1ee7a vi\u1ec7c cung c\u1ea5p c\u00e1c men vi sinh s\u1ed1ng qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, nh\u1ea5t l\u00e0 tr\u00ean \u0111\u1ed9ng v\u1eadt s\u01a1 sinh \u0111\u1ec3 ch\u00fang gi\u00fap k\u00edch th\u00edch ph\u1ea3n \u1ee9ng chuy\u1ec3n l\u1edbp chu\u1ed7i n\u1eb7ng v\u00e0 s\u1ea3n xu\u1ea5t IgA th\u00f4ng qua c\u00e1c y\u1ebfu t\u1ed1 BAFF v\u00e0 APRIL \u0111\u01b0\u1ee3c tr\u00ecnh b\u00e0y \u1edf ph\u1ea7n sau.<\/p>\n\n\n\nB\u00ean c\u1ea1nh \u0111\u00f3, nh\u1eefng quan s\u00e1t khoa h\u1ecdc hi\u1ec7n t\u1ea1i cho th\u1ea5y r\u1eb1ng h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t gi\u1eef vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c \u0111i\u1ec1u h\u00f2a s\u1ef1 h\u00ecnh th\u00e0nh h\u1ec7 th\u1ed1ng ph\u00f2ng th\u1ee7 c\u1ee7a \u0111\u01b0\u1eddng ru\u1ed9t:<\/p>\n\n\n\n
1\/ Ch\u00fang ph\u00e1t ra nh\u1eefng t\u00edn hi\u1ec7u h\u01b0\u1edbng d\u1eabn cho s\u1ef1 h\u00ecnh th\u00e0nh c\u1ee7a c\u00e1c nh\u00f3m lympho b\u00e0o then ch\u1ed1t;<\/p>\n\n\n\n
2\/ Ch\u00fang \u0111i\u1ec1u khi\u1ec3n s\u1ef1 chuy\u1ec3n l\u1edbp chu\u1ed7i n\u1eb7ng c\u1ee7a lympho B;<\/p>\n\n\n\n
3\/ Ch\u00fang \u1ee9c ch\u1ebf vi\u1ec7c s\u1ea3n xu\u1ea5t th\u00eam c\u00e1c lympho T \u0111i\u1ec1u h\u00f2a (Treg);<\/p>\n\n\n\n
4\/ Ch\u00fang k\u00edch th\u00edch s\u1ef1 h\u00ecnh th\u00e0nh nh\u00f3m lympho T gi\u00fap ti\u1ebft interleukin 17 (g\u1ecdi l\u00e0 TH<\/sub>17, t\u1ebf b\u00e0o n\u00e0y ti\u1ebft cytokine nh\u01b0 IL17, IL22 c\u00f3 vai tr\u00f2 k\u00edch th\u00edch t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 ru\u1ed9t s\u1ea3n xu\u1ea5t protein kh\u00e1ng khu\u1ea9n nh\u01b0 n\u1ea5m Candida, vi khu\u1ea9n Staphylococcus\u2026, thi\u1ebfu h\u1ee5t TH<\/sub>17 th\u01b0\u1eddng m\u1eabn c\u1ea3m v\u1edbi c\u00e1c b\u1ec7nh do vi khu\u1ea9n c\u01a1 h\u1ed9i);<\/p>\n\n\n\n5\/ Ch\u00fang c\u0169ng gi\u00e1n ti\u1ebfp quy\u1ebft \u0111\u1ecbnh s\u1ef1 h\u00ecnh th\u00e0nh c\u1ee7a \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch th\u00edch \u1ee9ng \u0111\u1eb7c hi\u1ec7u to\u00e0n th\u00e2n th\u00f4ng qua vi\u1ec7c \u0111i\u1ec1u h\u00f2a t\u1ef7 l\u1ec7 lympho T gi\u00fap TH<\/sub>1 v\u00e0 TH<\/sub>2. Nh\u01b0 \u0111\u00e3 \u0111\u1ec1 c\u1eadp \u1edf tr\u00ean, \u0111\u1ed9ng v\u1eadt s\u01a1 sinh c\u00f3 \u0111\u00e1p \u1ee9ng TH<\/sub>1 th\u1ea5p, \u0111\u1ec3 c\u1ea3i thi\u1ec7n \u0111i\u1ec1u n\u00e0y, c\u1ea7n ph\u1ea3i c\u00f3 s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a nhi\u1ec1u lo\u1ea1i vi sinh v\u1eadt v\u1edbi s\u1ed1 l\u01b0\u1ee3ng cao trong \u0111\u01b0\u1eddng ru\u1ed9t nh\u1eb1m t\u1ea1o ra c\u00e1c k\u00edch th\u00edch \u0111\u1ed1i v\u1edbi h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch.<\/p>\n\n\n\nC\u01a1 ch\u1ebf \u0111i\u1ec1u h\u00f2a<\/strong>: bi\u1ec3u m\u00f4 ru\u1ed9t v\u00e0 c\u00e1c m\u00f4 lympho c\u1ee7a ru\u1ed9t c\u00f3 m\u1ed9t s\u1ed1 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch \u0111\u1ec3 tr\u00e1nh t\u00ecnh tr\u1ea1ng x\u1ea3y ra ph\u1ea3n \u1ee9ng qu\u00e1 m\u1ee9c d\u1eabn \u0111\u1ebfn s\u1ef1 h\u00ecnh th\u00e0nh nh\u1eefng \u1ed5 vi\u00eam l\u1edbn g\u00e2y t\u1ed5n h\u1ea1i c\u01a1 quan. Ng\u01b0\u1eddi ta quan s\u00e1t th\u1ea5y r\u1eb1ng c\u00e1c t\u1ebf b\u00e0o tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean hi\u1ec7n di\u1ec7n trong m\u00f4 ru\u1ed9t bi\u1ec3u hi\u1ec7n c\u00e1c th\u1ee5 th\u1ec3 t\u1ea7m so\u00e1t vi sinh v\u1eadt TLR \u1edf m\u1ee9c r\u1ea5t th\u1ea5p. \u0110i\u1ec1u n\u00e0y gi\u00fap ch\u00fang tr\u00e1nh k\u00edch th\u00edch h\u00ecnh th\u00e0nh \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch \u0111\u1ed1i v\u1edbi nh\u1eefng nh\u00f3m nh\u1ecf vi khu\u1ea9n c\u00f3 l\u1ee3i \u0111\u01b0\u1eddng ru\u1ed9t m\u00e0 th\u01b0\u1eddng x\u00e2m nh\u1eadp xuy\u00ean qua bi\u1ec3u m\u00f4 v\u00e0 l\u1edbp m\u00e0ng nh\u1ea7y ru\u1ed9t.<\/p>\n\n\n\n![\"\"](\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/image003.jpg\")
<\/figure><\/div>\n\n\n\nH\u00ecnh \u2018Th\u1ee5 th\u1ec3 TLR\u2019 m\u00f4 t\u1ea3 c\u00e1c lo\u1ea1i th\u1ee5 th\u1ec3 TLR ch\u00ednh \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh hi\u1ec7n di\u1ec7n tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o. Ch\u00fang bao g\u1ed3m TLR2, TLR4, TLR5 v\u00e0 TLR6. Trong \u0111\u00f3, TLR4 v\u00e0 TLR5 ho\u1ea1t \u0111\u1ed9ng \u0111\u1ed9c l\u1eadp. TLR4 \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh c\u00f3 kh\u1ea3 n\u0103ng nh\u1eadn di\u1ec7n lipopolysaccharide (LPS) c\u1ee7a c\u00e1c vi khu\u1ea9n gram \u00e2m, \u0111\u1ed9c t\u1ed1 taxol \u1edf th\u1ef1c v\u1eadt, F protein c\u1ee7a virus g\u00e2y b\u1ec7nh h\u00f4 h\u1ea5p RSV v\u00e0 m\u1ed9t s\u1ed1 protein c\u1ee7a ch\u00ednh c\u01a1 th\u1ec3 v\u1eadt ch\u1ee7 nh\u01b0 HSP60 v\u00e0 fibronectin. TLR5 chuy\u00ean nh\u1eadn di\u1ec7n kh\u00e1ng nguy\u00ean ti\u00eam mao (Flagellin). Ng\u01b0\u1ee3c l\u1ea1i, TLR2 v\u00e0 TLR6 lu\u00f4n b\u1eaft c\u1eb7p v\u1edbi nhau \u0111\u1ec3 h\u1ee3p th\u00e0nh m\u1ed9t lo\u1ea1i th\u1ee5 th\u1ec3 c\u00f3 kh\u1ea3 n\u0103ng nh\u1eadn di\u1ec7n LPS c\u1ee7a m\u1ed9t s\u1ed1 vi khu\u1ea9n nh\u01b0 xo\u1eafn khu\u1ea9n Leptospira, vi khu\u1ea9n gram \u00e2m y\u1ebfm kh\u00ed Porphyromonas gingivalis, c\u00e1c lipoprotein, th\u00e0nh ph\u1ea7n peptidoglycan c\u1ee7a vi khu\u1ea9n, zymosan trong m\u00e0ng t\u1ebf b\u00e0o n\u1ea5m men (yeast)\u2026<\/p>\n\n\n\n
Qu\u00e1 tr\u00ecnh ho\u00e0n thi\u1ec7n c\u1ee7a c\u00e1c c\u01a1 ch\u1ebf \u0111\u1ec1 kh\u00e1ng v\u00e0 h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch sau sinh di\u1ec5n ra nhanh hay ch\u1eadm t\u00f9y thu\u1ed9c v\u00e0o nhi\u1ec1u y\u1ebfu t\u1ed1 kh\u00e1c nhau. Trong \u0111\u00f3, c\u00e1c y\u1ebfu t\u1ed1 quan tr\u1ecdng nh\u1ea5t l\u00e0 s\u1ef1 c\u00e2n b\u1eb1ng c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t, th\u1eddi gian v\u00e0 li\u1ec1u l\u01b0\u1ee3ng m\u00e0 nh\u1eefng vi sinh v\u1eadt c\u0169ng nh\u01b0 nh\u1eefng kh\u00e1ng nguy\u00ean m\u1edbi l\u1ea1, l\u1ea7n \u0111\u1ea7u \u0111i v\u00e0o trong \u0111\u01b0\u1eddng ti\u00eau h\u00f3a qua th\u1ee9c \u0103n v\u00e0 n\u01b0\u1edbc u\u1ed1ng. Nh\u1eefng ng\u00e0y \u0111\u1ea7u ti\u00ean \u0111\u1ed1i v\u1edbi v\u1eadt nu\u00f4i, hay nh\u1eefng n\u0103m \u0111\u1ea7u ti\u00ean \u0111\u1ed1i v\u1edbi con ng\u01b0\u1eddi l\u00e0 th\u1eddi gian quan tr\u1ecdng nh\u1ea5t \u0111\u1ec3 h\u00ecnh th\u00e0nh \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch v\u00e0 th\u00f3i quen \u0103n u\u1ed1ng. Nh\u1eefng y\u1ebfu t\u1ed1 kh\u00e1c nh\u01b0 s\u1eefa m\u1eb9, s\u1eefa thay th\u1ebf hay vi\u1ec7c s\u1eed d\u1ee5ng kh\u00e1ng sinh, men ti\u00eau h\u00f3a c\u00f9ng c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c trong th\u1ee9c \u0103n n\u01b0\u1edbc u\u1ed1ng c\u0169ng g\u00f3p ph\u1ea7n \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 c\u00e2n b\u1eb1ng c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t, t\u00ednh to\u00e0n v\u1eb9n c\u1ee7a bi\u1ec3u m\u00f4 \u0111\u01b0\u1eddng ti\u00eau h\u00f3a v\u00e0 t\u00ednh ho\u00e0n thi\u1ec7n c\u1ee7a \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch.<\/p>\n\n\n\n
Bi\u00ean so\u1ea1n: TS. BSTY. \u0110inh Xu\u00e2n Ph\u00e1t<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"M\u1eb7c d\u00f9 tr\u1ebb hay th\u00fa s\u01a1 sinh m\u1ea1nh kh\u1ecfe \u0111\u1ec1u c\u00f3 m\u1ed9t h\u1ec7 mi\u1ec5n d\u1ecbch \u2018c\u00f3 n\u0103ng l\u1ef1c \u0111\u1ea7y \u0111\u1ee7\u2019 (competent) \u0111\u1ec3 thi\u1ebft l\u1eadp m\u1ed9t \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch \u0111\u1ea7y \u0111\u1ee7 \u0111\u1ed1i v\u1edbi m\u1ed9t kh\u00e1ng nguy\u00ean l\u1ea1 hay vacxin. Tuy nhi\u00ean, v\u1ec1 c\u01a1 ch\u1ebf h\u00ecnh th\u00e0nh \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch th\u00ec c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t r\u00f5 r\u1ec7t gi\u1eefa th\u00fa non v\u00e0 th\u00fa tr\u01b0\u1edfng th\u00e0nh, v\u00ec ba y\u1ebfu t\u1ed1 ch\u00ednh.<\/p>\n","protected":false},"author":4,"featured_media":8012,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"footnotes":""},"categories":[3,2],"tags":[39,55,32,56,54],"class_list":["post-8014","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-chan-nuoi","category-sinh-hoc","tag-che-pham-sinh-hoc","tag-men-tieu-hoa","tag-men-vi-sinh","tag-mien-dich","tag-proobiotic"],"yoast_head":"\n
Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P2 - H\u1ea3i H\u01b0ng Probiotics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hhbio.vn\/?p=8014\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P2\" \/>\n<meta property=\"og:description\" content=\"M\u1eb7c d\u00f9 tr\u1ebb hay th\u00fa s\u01a1 sinh m\u1ea1nh kh\u1ecfe \u0111\u1ec1u c\u00f3 m\u1ed9t h\u1ec7 mi\u1ec5n d\u1ecbch \u2018c\u00f3 n\u0103ng l\u1ef1c \u0111\u1ea7y \u0111\u1ee7\u2019 (competent) \u0111\u1ec3 thi\u1ebft l\u1eadp m\u1ed9t \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch \u0111\u1ea7y \u0111\u1ee7 \u0111\u1ed1i v\u1edbi m\u1ed9t kh\u00e1ng nguy\u00ean l\u1ea1 hay vacxin. Tuy nhi\u00ean, v\u1ec1 c\u01a1 ch\u1ebf h\u00ecnh th\u00e0nh \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch th\u00ec c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t r\u00f5 r\u1ec7t gi\u1eefa th\u00fa non v\u00e0 th\u00fa tr\u01b0\u1edfng th\u00e0nh, v\u00ec ba y\u1ebfu t\u1ed1 ch\u00ednh.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hhbio.vn\/?p=8014\" \/>\n<meta property=\"og:site_name\" content=\"H\u1ea3i H\u01b0ng Probiotics\" \/>\n<meta property=\"article:published_time\" content=\"2019-02-27T04:21:35+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-02-27T04:22:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"445\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"17 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/hhbio.vn\/?p=8014#article\",\"isPartOf\":{\"@id\":\"https:\/\/hhbio.vn\/?p=8014\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/hhbio.vn\/#\/schema\/person\/39485024c55ecf320ea3302bad2b6ef4\"},\"headline\":\"Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P2\",\"datePublished\":\"2019-02-27T04:21:35+00:00\",\"dateModified\":\"2019-02-27T04:22:42+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/hhbio.vn\/?p=8014\"},\"wordCount\":3412,\"publisher\":{\"@id\":\"https:\/\/hhbio.vn\/#organization\"},\"image\":{\"@id\":\"https:\/\/hhbio.vn\/?p=8014#primaryimage\"},\"thumbnailUrl\":\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg\",\"keywords\":[\"ch\u1ebf ph\u1ea9m sinh h\u1ecdc\",\"men ti\u00eau h\u00f3a\",\"men vi sinh\",\"mi\u1ec5n d\u1ecbch\",\"proobiotic\"],\"articleSection\":[\"Ch\u0103n nu\u00f4i\",\"Sinh h\u1ecdc\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/hhbio.vn\/?p=8014\",\"url\":\"https:\/\/hhbio.vn\/?p=8014\",\"name\":\"Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P2 - H\u1ea3i H\u01b0ng Probiotics\",\"isPartOf\":{\"@id\":\"https:\/\/hhbio.vn\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/hhbio.vn\/?p=8014#primaryimage\"},\"image\":{\"@id\":\"https:\/\/hhbio.vn\/?p=8014#primaryimage\"},\"thumbnailUrl\":\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg\",\"datePublished\":\"2019-02-27T04:21:35+00:00\",\"dateModified\":\"2019-02-27T04:22:42+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/hhbio.vn\/?p=8014#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/hhbio.vn\/?p=8014\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/hhbio.vn\/?p=8014#primaryimage\",\"url\":\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg\",\"contentUrl\":\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg\",\"width\":800,\"height\":445},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/hhbio.vn\/?p=8014#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/hhbio.vn\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P2\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/hhbio.vn\/#website\",\"url\":\"https:\/\/hhbio.vn\/\",\"name\":\"BIOTEKCO\",\"description\":\"Building Products For You\",\"publisher\":{\"@id\":\"https:\/\/hhbio.vn\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/hhbio.vn\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/hhbio.vn\/#organization\",\"name\":\"BIOTEKCO.,LTD\",\"url\":\"https:\/\/hhbio.vn\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/hhbio.vn\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/01\/logo-cmyk-01-1-e1560779045791.png\",\"contentUrl\":\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/01\/logo-cmyk-01-1-e1560779045791.png\",\"width\":216,\"height\":90,\"caption\":\"BIOTEKCO.,LTD\"},\"image\":{\"@id\":\"https:\/\/hhbio.vn\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/hhbio.vn\/#\/schema\/person\/39485024c55ecf320ea3302bad2b6ef4\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/hhbio.vn\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/60ff287c3f4ad60471147e6035b7a6ab4e48cf6d5733f6bc839ca2a2caee08df?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/60ff287c3f4ad60471147e6035b7a6ab4e48cf6d5733f6bc839ca2a2caee08df?s=96&d=mm&r=g\",\"caption\":\"admin\"}}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P2 - H\u1ea3i H\u01b0ng Probiotics","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/hhbio.vn\/?p=8014","og_locale":"en_US","og_type":"article","og_title":"Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P2","og_description":"M\u1eb7c d\u00f9 tr\u1ebb hay th\u00fa s\u01a1 sinh m\u1ea1nh kh\u1ecfe \u0111\u1ec1u c\u00f3 m\u1ed9t h\u1ec7 mi\u1ec5n d\u1ecbch \u2018c\u00f3 n\u0103ng l\u1ef1c \u0111\u1ea7y \u0111\u1ee7\u2019 (competent) \u0111\u1ec3 thi\u1ebft l\u1eadp m\u1ed9t \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch \u0111\u1ea7y \u0111\u1ee7 \u0111\u1ed1i v\u1edbi m\u1ed9t kh\u00e1ng nguy\u00ean l\u1ea1 hay vacxin. Tuy nhi\u00ean, v\u1ec1 c\u01a1 ch\u1ebf h\u00ecnh th\u00e0nh \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch th\u00ec c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t r\u00f5 r\u1ec7t gi\u1eefa th\u00fa non v\u00e0 th\u00fa tr\u01b0\u1edfng th\u00e0nh, v\u00ec ba y\u1ebfu t\u1ed1 ch\u00ednh.","og_url":"https:\/\/hhbio.vn\/?p=8014","og_site_name":"H\u1ea3i H\u01b0ng Probiotics","article_published_time":"2019-02-27T04:21:35+00:00","article_modified_time":"2019-02-27T04:22:42+00:00","og_image":[{"width":800,"height":445,"url":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg","type":"image\/jpeg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Written by":"admin","Est. reading time":"17 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/hhbio.vn\/?p=8014#article","isPartOf":{"@id":"https:\/\/hhbio.vn\/?p=8014"},"author":{"name":"admin","@id":"https:\/\/hhbio.vn\/#\/schema\/person\/39485024c55ecf320ea3302bad2b6ef4"},"headline":"Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P2","datePublished":"2019-02-27T04:21:35+00:00","dateModified":"2019-02-27T04:22:42+00:00","mainEntityOfPage":{"@id":"https:\/\/hhbio.vn\/?p=8014"},"wordCount":3412,"publisher":{"@id":"https:\/\/hhbio.vn\/#organization"},"image":{"@id":"https:\/\/hhbio.vn\/?p=8014#primaryimage"},"thumbnailUrl":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg","keywords":["ch\u1ebf ph\u1ea9m sinh h\u1ecdc","men ti\u00eau h\u00f3a","men vi sinh","mi\u1ec5n d\u1ecbch","proobiotic"],"articleSection":["Ch\u0103n nu\u00f4i","Sinh h\u1ecdc"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/hhbio.vn\/?p=8014","url":"https:\/\/hhbio.vn\/?p=8014","name":"Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P2 - H\u1ea3i H\u01b0ng Probiotics","isPartOf":{"@id":"https:\/\/hhbio.vn\/#website"},"primaryImageOfPage":{"@id":"https:\/\/hhbio.vn\/?p=8014#primaryimage"},"image":{"@id":"https:\/\/hhbio.vn\/?p=8014#primaryimage"},"thumbnailUrl":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg","datePublished":"2019-02-27T04:21:35+00:00","dateModified":"2019-02-27T04:22:42+00:00","breadcrumb":{"@id":"https:\/\/hhbio.vn\/?p=8014#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/hhbio.vn\/?p=8014"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/hhbio.vn\/?p=8014#primaryimage","url":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg","contentUrl":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg","width":800,"height":445},{"@type":"BreadcrumbList","@id":"https:\/\/hhbio.vn\/?p=8014#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/hhbio.vn\/"},{"@type":"ListItem","position":2,"name":"Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P2"}]},{"@type":"WebSite","@id":"https:\/\/hhbio.vn\/#website","url":"https:\/\/hhbio.vn\/","name":"BIOTEKCO","description":"Building Products For You","publisher":{"@id":"https:\/\/hhbio.vn\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/hhbio.vn\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/hhbio.vn\/#organization","name":"BIOTEKCO.,LTD","url":"https:\/\/hhbio.vn\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/hhbio.vn\/#\/schema\/logo\/image\/","url":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/01\/logo-cmyk-01-1-e1560779045791.png","contentUrl":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/01\/logo-cmyk-01-1-e1560779045791.png","width":216,"height":90,"caption":"BIOTEKCO.,LTD"},"image":{"@id":"https:\/\/hhbio.vn\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/hhbio.vn\/#\/schema\/person\/39485024c55ecf320ea3302bad2b6ef4","name":"admin","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/hhbio.vn\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/60ff287c3f4ad60471147e6035b7a6ab4e48cf6d5733f6bc839ca2a2caee08df?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/60ff287c3f4ad60471147e6035b7a6ab4e48cf6d5733f6bc839ca2a2caee08df?s=96&d=mm&r=g","caption":"admin"}}]}},"_links":{"self":[{"href":"https:\/\/hhbio.vn\/index.php?rest_route=\/wp\/v2\/posts\/8014","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hhbio.vn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hhbio.vn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hhbio.vn\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/hhbio.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8014"}],"version-history":[{"count":0,"href":"https:\/\/hhbio.vn\/index.php?rest_route=\/wp\/v2\/posts\/8014\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/hhbio.vn\/index.php?rest_route=\/wp\/v2\/media\/8012"}],"wp:attachment":[{"href":"https:\/\/hhbio.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8014"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hhbio.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=8014"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hhbio.vn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=8014"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/figure><\/div>\n\n\n\nH\u00ecnh \u2018T\u01b0\u01a1ng t\u00e1c gi\u1eefa c\u00e1c t\u1ebf b\u00e0o\u2019 cho th\u1ea5y lympho T ho\u1ea1t h\u00f3a d\u00f9ng ph\u00e2n t\u1eed b\u1ec1 m\u1eb7t PSGL1 ho\u1eb7c E-selectin ligand \u0111\u1ec3 ti\u1ebfp x\u00fac v\u1edbi ph\u00e2n t\u1eed P-selectin ho\u1eb7c E-selectin bi\u1ec3u hi\u1ec7n tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 t\u1ea1i v\u00f9ng vi\u00eam. Trong m\u00f4 vi\u00eam m\u00e3n t\u00ednh, th\u00ec ngo\u00e0i P-selectin v\u00e0 E-selectin, t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 c\u00f2n bi\u1ec3u hi\u1ec7n th\u00eam ph\u00e2n t\u1eed b\u1ec1 m\u1eb7t PNAD c\u00f3 kh\u1ea3 n\u0103ng ti\u1ebfp x\u00fac v\u1edbi ph\u00e2n t\u1eed L-selectin bi\u1ec3u hi\u1ec7n tr\u00ean lympho T ng\u00e2y th\u01a1. Trong khi \u0111\u00f3, khi c\u00e1c b\u1ea1ch c\u1ea7u trung t\u00ednh, b\u1ea1ch c\u1ea7u \u0111\u01a1n nh\u00e2n hay c\u00e1c h\u1ea1t do b\u1ea1ch c\u1ea7u \u0111\u01a1n nh\u00e2n v\u00e0 ti\u1ec3u c\u1ea7u ti\u1ebft ra \u0111\u00e3 ti\u1ebfp x\u00fac v\u00e0 chi\u1ebfm \u0111\u00f3ng tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 t\u1ea1i c\u00e1c m\u00f4 vi\u00eam, th\u00ec ch\u00fang s\u1ebd bi\u1ec3u hi\u1ec7n ph\u00e2n t\u1eed PSGL1 \u0111\u1ec3 t\u1ea1o ra ch\u1ed7 b\u00e1m cho c\u00e1c lympho T ng\u00e2y th\u01a1, lympho T ho\u1ea1t h\u00f3a ho\u1eb7c lympho T nh\u1edb.<\/p>\n\n\n\n
H\u01a1n n\u1eefa, c\u00e1c t\u1ebf b\u00e0o tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean (APC, g\u1ed3m t\u1ebf b\u00e0o tua, \u0111\u1ea1i th\u1ef1c b\u00e0o, lympho B; xem th\u00eam trong ph\u1ea7n \u2018C\u00e1c t\u1ebf b\u00e0o tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean\u2019) c\u1ee7a th\u00fa non c\u0169ng ho\u1ea1t \u0111\u1ed9ng v\u00e0 ph\u00e2n ti\u1ebft cytokine k\u00e9m h\u01a1n. L\u00fd do l\u00e0 v\u00ec ch\u00fang bi\u1ec3u hi\u1ec7n v\u1edbi s\u1ed1 l\u01b0\u1ee3ng th\u1ea5p \u0111\u1ed1i v\u1edbi c\u00e1c th\u1ee5 th\u1ec3 v\u00e0 ph\u00e2n t\u1eed b\u1ec1 m\u1eb7t quan tr\u1ecdng nh\u01b0 MHC I, MHC II, th\u1ee5 th\u1ec3 \u0111\u1ed3ng ho\u1ea1t h\u00f3a B7; \u0111\u1ed3ng th\u1eddi ho\u1ea1t t\u00ednh th\u1ef1c b\u00e0o (phagocytosis), nh\u1eadp b\u00e0o (endocytosis) v\u00e0 h\u00f3a h\u01b0\u1edbng \u0111\u1ed9ng (chemotaxis) c\u1ee7a ch\u00fang c\u0169ng ch\u01b0a m\u1ea1nh. B\u00ean c\u1ea1nh \u0111\u00f3, ho\u1ea1t \u0111\u1ed9ng t\u1ea7m so\u00e1t v\u00e0 ti\u00eau di\u1ec7t t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh, t\u1ebf b\u00e0o b\u1ecb nhi\u1ec5m, t\u1ebf b\u00e0o bi\u1ebfn th\u00e1i\u00a0 c\u1ee7a c\u1edf th\u1ec3 do t\u1ebf b\u00e0o NK ph\u1ee5 tr\u00e1ch c\u0169ng c\u00f2n y\u1ebfu tr\u00ean \u0111\u1ed9ng v\u1eadt s\u01a1 sinh. \u0110\u1ec3 hi\u1ec3u r\u00f5 th\u00eam v\u1ec1 ch\u1ee9c n\u0103ng c\u1ee7a t\u1ebf b\u00e0o gi\u1ebft t\u1ef1 nhi\u00ean NK, xin tham kh\u1ea3o ph\u1ea7n \u2018T\u1ebf b\u00e0o gi\u1ebft t\u1ef1 nhi\u00ean\u2019.<\/p>\n\n\n\n
\u0110\u00e1p \u1ee9ng c\u1ee7a lympho T v\u1edbi kh\u00e1ng nguy\u00ean \u1edf \u0111\u1ed9ng v\u1eadt s\u01a1 sinh y\u1ebfu h\u01a1n \u1edf \u0111\u1ed9ng v\u1eadt tr\u01b0\u1edfng th\u00e0nh, th\u1ec3 hi\u1ec7n th\u00f4ng qua m\u1ee9c s\u1ea3n xu\u1ea5t IFN\u03b3 th\u1ea5p, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch qua trung gian t\u1ebf b\u00e0o li\u00ean quan \u0111\u1ebfn lympho CD4 TH<\/sub>1 v\u00e0 CD8 T (lympho CD8 T sau khi ho\u1ea1t h\u00f3a c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 CTL hay Tc). B\u1edfi v\u1eady, n\u00f3i chung l\u00e0 tr\u00ean \u0111\u1ed9ng v\u1eadt s\u01a1 sinh, \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch th\u00edch \u1ee9ng \u0111\u1eb7c hi\u1ec7u x\u1ea3y ra m\u1ea1nh h\u01a1n \u1edf ph\u1ea7n mi\u1ec5n d\u1ecbch d\u1ecbch th\u1ec3 do lympho B ph\u1ee5 tr\u00e1ch v\u1edbi s\u1ef1 h\u1ed7 tr\u1ee3 c\u1ee7a TH<\/sub>2. M\u1eb7c d\u00f9 m\u1ed9t s\u1ed1 kh\u00e1ng nguy\u00ean vacxin m\u1ea1nh c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t c\u1ea3 ph\u1ea7n mi\u1ec5n d\u1ecbch qua trung gian t\u1ebf b\u00e0o do lympho CD8 T v\u00e0 CD4 TDTH<\/sub> (lympho T qu\u00e1 m\u1eabn mu\u1ed9n) ph\u1ee5 tr\u00e1ch v\u1edbi s\u1ef1 h\u1ed7 tr\u1ee3 c\u1ee7a CD4 TH<\/sub>1, nh\u01b0ng h\u1ea7u h\u1ebft c\u00e1c vacxin trung b\u00ecnh \u0111\u1ec1u ch\u1ee7 y\u1ebfu k\u00edch th\u00edch mi\u1ec5n d\u1ecbch d\u1ecbch th\u1ec3.<\/p>\n\n\n\n \u0110\u1ec3 hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 hai ph\u1ea7n c\u1ee7a \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch th\u00edch \u1ee9ng \u0111\u1eb7c hi\u1ec7u, xin tham kh\u1ea3o ph\u1ea7n \u2018\u0110\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch d\u1ecbch th\u1ec3\u2019 v\u00e0 \u2018\u0110\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch qua trung gian t\u1ebf b\u00e0o\u2019. H\u01a1n n\u1eefa, l\u01b0\u1ee3ng lympho T c\u00f3 ch\u1ee9c n\u0103ng \u1ee9c ch\u1ebf \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch (g\u1ecdi l\u00e0 Treg) l\u1ea1i hi\u1ec7n di\u1ec7n v\u1edbi s\u1ed1 l\u01b0\u1ee3ng l\u1edbn h\u01a1n tr\u00ean \u0111\u1ed9ng v\u1eadt s\u01a1 sinh.<\/p>\n\n\n\n T\u00f3m l\u1ea1i, c\u00e1c t\u1ebf b\u00e0o hay c\u00e1c ch\u1ea5t tham gia \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch b\u1ea9m sinh c\u0169ng nh\u01b0 th\u00edch \u1ee9ng \u0111\u1ec1u c\u00f2n \u0111ang \u1edf trong tr\u1ea1ng th\u00e1i ph\u00e1t tri\u1ec3n, ch\u01b0a ho\u00e0n thi\u1ec7n tr\u00ean \u0111\u1ed9ng v\u1eadt s\u01a1 sinh. \u0110\u1eb7c tr\u01b0ng c\u1ee7a c\u00e1c th\u00e0nh ph\u1ea7n c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch l\u00e0 ch\u00fang c\u00f3 m\u1ed9i quan h\u1ec7 b\u1ed5 tr\u1ee3 l\u1eabn nhau. V\u00ec v\u1eady, ng\u01b0\u1eddi ta gi\u1ea3i th\u00edch r\u1eb1ng \u0111\u00e1p \u1ee9ng y\u1ebfu k\u00e9m c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch tr\u00ean th\u00fa s\u01a1 sinh m\u1ed9t ph\u1ea7n ch\u00ednh l\u00e0 do thi\u1ebfu v\u1eafng s\u1ef1 h\u1ed7 tr\u1ee3 l\u1eabn nhau n\u00e0y.<\/p>\n\n\n\n S\u1ed1 l\u01b0\u1ee3ng lympho B tr\u00ean \u0111\u1ed9ng v\u1eadt s\u01a1 sinh l\u00e0 r\u1ea5t cao, nh\u01b0ng kh\u1ea3 n\u0103ng tr\u01b0\u1edfng th\u00e0nh, bi\u1ec7t h\u00f3a v\u00e0 chuy\u1ec3n l\u1edbp chu\u1ed7i n\u1eb7ng c\u1ee7a ch\u00fang c\u00f2n h\u1ea1n ch\u1ebf. Qu\u00e1 tr\u00ecnh bi\u1ec7t h\u00f3a x\u1ea3y ra l\u00e0 \u0111\u1ec3 bi\u1ebfn \u0111\u1ed5i lympho B th\u00e0nh t\u01b0\u01a1ng b\u00e0o (plasma cell) chuy\u00ean s\u1ea3n xu\u1ea5t kh\u00e1ng th\u1ec3, bao g\u1ed3m m\u1ed9t trong n\u0103m lo\u1ea1i IgA, IgM, IgG, IgD v\u00e0 IgE. Ban \u0111\u1ea7u, t\u1ea5t c\u1ea3 m\u1ecdi lympho B tr\u01b0\u1edfng th\u00e0nh \u0111\u1ec1u s\u1ea3n xu\u1ea5t IgM v\u00e0 IgD \u1edf d\u1ea1ng g\u1eafn tr\u00ean b\u1ec1 m\u1eb7t (H\u00ecnh \u2018Qu\u00e1 tr\u00ecnh tr\u01b0\u1edfng th\u00e0nh v\u00e0 bi\u1ec7t h\u00f3a lympho B\u2019, giai \u0111o\u1ea1n Lympho B tr\u01b0\u1edfng th\u00e0nh). Sau \u0111\u00f3, nh\u1edd qu\u00e1 tr\u00ecnh chuy\u1ec3n l\u1edbp chu\u1ed7i n\u1eb7ng, d\u01b0\u1edbi s\u1ef1 k\u00edch th\u00edch c\u1ee7a c\u00e1c cytokine v\u00e0 \u0111\u1eb7c bi\u1ec7t l\u00e0 cytokine c\u1ee7a lympho TH<\/sub>2 m\u00e0 ch\u00fang c\u00f3 th\u1ec3 bi\u1ec7t h\u00f3a th\u00e0nh c\u00e1c t\u01b0\u01a1ng b\u00e0o s\u1ea3n xu\u1ea5t c\u00e1c lo\u1ea1i kh\u00e1ng th\u1ec3 d\u1ea1ng ti\u1ebft (secreted immunoglobulin, sIg) g\u1ed3m sIgA, sIgM, IgG v\u00e0 IgE.<\/p>\n\n\n\n Song song v\u1edbi qu\u00e1 tr\u00ecnh bi\u1ec7t h\u00f3a th\u00e0nh t\u01b0\u01a1ng b\u00e0o, m\u1ed9t s\u1ed1 lympho B ph\u00e1t tri\u1ec3n th\u00e0nh t\u1eadp h\u1ee3p c\u00e1c lympho B nh\u1edb. C\u00e1c lympho B nh\u1edb n\u00e0y c\u00f3 kh\u1ea3 n\u0103ng nh\u1eadn di\u1ec7n kh\u00e1ng nguy\u00ean \u0111\u1eb7c hi\u1ec7u \u1edf l\u1ea7n ti\u1ebfp x\u00fac ti\u1ebfp theo v\u00e0 k\u00edch ho\u1ea1t \u0111\u00e1p \u1ee9ng s\u1ea3n xu\u1ea5t kh\u00e1ng th\u1ec3 \u0111\u1eb7c hi\u1ec7u m\u1ed9t c\u00e1ch nhanh ch\u00f3ng v\u00e0 m\u1ea1nh m\u1ebd h\u01a1n so v\u1edbi l\u1ea7n ti\u1ebfp x\u00fac \u0111\u1ea7u ti\u00ean. T\u1eadp h\u1ee3p lympho B nh\u1edb bao g\u1ed3m nhi\u1ec1u lo\u1ea1i t\u1ebf b\u00e0o B nh\u1edb kh\u00e1c nhau, m\u1ed7i lo\u1ea1i mang tr\u00ean b\u1ec1 m\u1eb7t c\u1ee7a n\u00f3 duy nh\u1ea5t m\u1ed9t lo\u1ea1i kh\u00e1ng th\u1ec3 b\u1ec1 m\u1eb7t (c\u00f2n g\u1ecdi l\u00e0 th\u1ee5 th\u1ec3 BCR) kh\u00e1c nhau (g\u1ed3m IgM, IgG, IgA, IgE) t\u01b0\u01a1ng \u1ee9ng v\u1edbi m\u1ed7i lo\u1ea1i kh\u00e1ng th\u1ec3 \u0111\u1eb7c hi\u1ec7u d\u1ea1ng ti\u1ebft m\u00e0 ch\u00fang s\u1ebd s\u1ea3n xu\u1ea5t ra khi b\u1ecb k\u00edch th\u00edch. Kh\u00e1ng th\u1ec3 IgD ch\u1ec9 c\u00f3 \u1edf d\u1ea1ng b\u00e1m tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o lympho B \u1edf giai \u0111o\u1ea1n lympho B tr\u01b0\u1edfng th\u00e0nh, n\u00f3 kh\u00f4ng \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t \u1edf d\u1ea1ng ti\u1ebft v\u00e0 cho \u0111\u1ebfn nay ng\u01b0\u1eddi ta v\u1eabn chia hi\u1ec3u bi\u1ebft nhi\u1ec1u v\u1ec1 vai tr\u00f2 c\u1ee7a IgD trong \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch. \u0110\u1ec3 hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 c\u00e1c lo\u1ea1i kh\u00e1ng th\u1ec3, xin tham kh\u1ea3o ph\u1ea7n \u2018Kh\u00e1ng th\u1ec3\u2019.<\/p>\n\n\n\n Tr\u00ean \u0111\u1ed9ng v\u1eadt s\u01a1 sinh, ngo\u00e0i kh\u00e1ng th\u1ec3 IgG nh\u1eadn \u0111\u01b0\u1ee3c t\u1eeb m\u1eb9 th\u00f4ng qua nhau thai, qua s\u1eefa \u0111\u1ea7u v\u00e0 s\u1eefa, c\u00e1c kh\u00e1ng th\u1ec3 t\u1ef1 th\u00e2n s\u1ea3n xu\u1ea5t ra r\u1ea5t th\u1ea5p. IgA h\u1ea7u nh\u01b0 kh\u00f4ng c\u00f3. IgM r\u1ea5t th\u1ea5p m\u1eb7c d\u00f9 n\u00f3 s\u1ebd t\u0103ng nhanh ch\u00f3ng sau khi c\u00f3 s\u1ef1 k\u00edch th\u00edch c\u1ee7a kh\u00e1ng nguy\u00ean \u0111\u1ed1i v\u1edbi lympho B. M\u1ee9c \u0111\u1ed9 c\u1ee7a IgE c\u0169ng r\u1ea5t th\u1ea5p v\u00ec vi\u1ec7c s\u1ea3n xu\u1ea5t IgE \u0111\u00f2i h\u1ecfi ph\u1ea3i c\u00f3 s\u1ef1 h\u1ed7 tr\u1ee3 c\u1ee7a IL4 t\u1eeb lympho TH<\/sub>2, m\u00e0 lympho TH<\/sub>2 ch\u01b0a ho\u1ea1t \u0111\u1ed9ng m\u1ea1nh \u1edf tu\u1ed5i s\u01a1 sinh. \u0110i\u1ec1u n\u00e0y m\u1ed9t l\u1ea7n n\u1eefa cho th\u1ea5y t\u1ea7m quan tr\u1ecdng c\u1ee7a vi\u1ec7c cung c\u1ea5p c\u00e1c men vi sinh s\u1ed1ng qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, nh\u1ea5t l\u00e0 tr\u00ean \u0111\u1ed9ng v\u1eadt s\u01a1 sinh \u0111\u1ec3 ch\u00fang gi\u00fap k\u00edch th\u00edch ph\u1ea3n \u1ee9ng chuy\u1ec3n l\u1edbp chu\u1ed7i n\u1eb7ng v\u00e0 s\u1ea3n xu\u1ea5t IgA th\u00f4ng qua c\u00e1c y\u1ebfu t\u1ed1 BAFF v\u00e0 APRIL \u0111\u01b0\u1ee3c tr\u00ecnh b\u00e0y \u1edf ph\u1ea7n sau.<\/p>\n\n\n\n B\u00ean c\u1ea1nh \u0111\u00f3, nh\u1eefng quan s\u00e1t khoa h\u1ecdc hi\u1ec7n t\u1ea1i cho th\u1ea5y r\u1eb1ng h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t gi\u1eef vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c \u0111i\u1ec1u h\u00f2a s\u1ef1 h\u00ecnh th\u00e0nh h\u1ec7 th\u1ed1ng ph\u00f2ng th\u1ee7 c\u1ee7a \u0111\u01b0\u1eddng ru\u1ed9t:<\/p>\n\n\n\n 1\/ Ch\u00fang ph\u00e1t ra nh\u1eefng t\u00edn hi\u1ec7u h\u01b0\u1edbng d\u1eabn cho s\u1ef1 h\u00ecnh th\u00e0nh c\u1ee7a c\u00e1c nh\u00f3m lympho b\u00e0o then ch\u1ed1t;<\/p>\n\n\n\n 2\/ Ch\u00fang \u0111i\u1ec1u khi\u1ec3n s\u1ef1 chuy\u1ec3n l\u1edbp chu\u1ed7i n\u1eb7ng c\u1ee7a lympho B;<\/p>\n\n\n\n 3\/ Ch\u00fang \u1ee9c ch\u1ebf vi\u1ec7c s\u1ea3n xu\u1ea5t th\u00eam c\u00e1c lympho T \u0111i\u1ec1u h\u00f2a (Treg);<\/p>\n\n\n\n 4\/ Ch\u00fang k\u00edch th\u00edch s\u1ef1 h\u00ecnh th\u00e0nh nh\u00f3m lympho T gi\u00fap ti\u1ebft interleukin 17 (g\u1ecdi l\u00e0 TH<\/sub>17, t\u1ebf b\u00e0o n\u00e0y ti\u1ebft cytokine nh\u01b0 IL17, IL22 c\u00f3 vai tr\u00f2 k\u00edch th\u00edch t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 ru\u1ed9t s\u1ea3n xu\u1ea5t protein kh\u00e1ng khu\u1ea9n nh\u01b0 n\u1ea5m Candida, vi khu\u1ea9n Staphylococcus\u2026, thi\u1ebfu h\u1ee5t TH<\/sub>17 th\u01b0\u1eddng m\u1eabn c\u1ea3m v\u1edbi c\u00e1c b\u1ec7nh do vi khu\u1ea9n c\u01a1 h\u1ed9i);<\/p>\n\n\n\n 5\/ Ch\u00fang c\u0169ng gi\u00e1n ti\u1ebfp quy\u1ebft \u0111\u1ecbnh s\u1ef1 h\u00ecnh th\u00e0nh c\u1ee7a \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch th\u00edch \u1ee9ng \u0111\u1eb7c hi\u1ec7u to\u00e0n th\u00e2n th\u00f4ng qua vi\u1ec7c \u0111i\u1ec1u h\u00f2a t\u1ef7 l\u1ec7 lympho T gi\u00fap TH<\/sub>1 v\u00e0 TH<\/sub>2. Nh\u01b0 \u0111\u00e3 \u0111\u1ec1 c\u1eadp \u1edf tr\u00ean, \u0111\u1ed9ng v\u1eadt s\u01a1 sinh c\u00f3 \u0111\u00e1p \u1ee9ng TH<\/sub>1 th\u1ea5p, \u0111\u1ec3 c\u1ea3i thi\u1ec7n \u0111i\u1ec1u n\u00e0y, c\u1ea7n ph\u1ea3i c\u00f3 s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a nhi\u1ec1u lo\u1ea1i vi sinh v\u1eadt v\u1edbi s\u1ed1 l\u01b0\u1ee3ng cao trong \u0111\u01b0\u1eddng ru\u1ed9t nh\u1eb1m t\u1ea1o ra c\u00e1c k\u00edch th\u00edch \u0111\u1ed1i v\u1edbi h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch.<\/p>\n\n\n\n C\u01a1 ch\u1ebf \u0111i\u1ec1u h\u00f2a<\/strong>: bi\u1ec3u m\u00f4 ru\u1ed9t v\u00e0 c\u00e1c m\u00f4 lympho c\u1ee7a ru\u1ed9t c\u00f3 m\u1ed9t s\u1ed1 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch \u0111\u1ec3 tr\u00e1nh t\u00ecnh tr\u1ea1ng x\u1ea3y ra ph\u1ea3n \u1ee9ng qu\u00e1 m\u1ee9c d\u1eabn \u0111\u1ebfn s\u1ef1 h\u00ecnh th\u00e0nh nh\u1eefng \u1ed5 vi\u00eam l\u1edbn g\u00e2y t\u1ed5n h\u1ea1i c\u01a1 quan. Ng\u01b0\u1eddi ta quan s\u00e1t th\u1ea5y r\u1eb1ng c\u00e1c t\u1ebf b\u00e0o tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean hi\u1ec7n di\u1ec7n trong m\u00f4 ru\u1ed9t bi\u1ec3u hi\u1ec7n c\u00e1c th\u1ee5 th\u1ec3 t\u1ea7m so\u00e1t vi sinh v\u1eadt TLR \u1edf m\u1ee9c r\u1ea5t th\u1ea5p. \u0110i\u1ec1u n\u00e0y gi\u00fap ch\u00fang tr\u00e1nh k\u00edch th\u00edch h\u00ecnh th\u00e0nh \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch \u0111\u1ed1i v\u1edbi nh\u1eefng nh\u00f3m nh\u1ecf vi khu\u1ea9n c\u00f3 l\u1ee3i \u0111\u01b0\u1eddng ru\u1ed9t m\u00e0 th\u01b0\u1eddng x\u00e2m nh\u1eadp xuy\u00ean qua bi\u1ec3u m\u00f4 v\u00e0 l\u1edbp m\u00e0ng nh\u1ea7y ru\u1ed9t.<\/p>\n\n\n\n H\u00ecnh \u2018Th\u1ee5 th\u1ec3 TLR\u2019 m\u00f4 t\u1ea3 c\u00e1c lo\u1ea1i th\u1ee5 th\u1ec3 TLR ch\u00ednh \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh hi\u1ec7n di\u1ec7n tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o. Ch\u00fang bao g\u1ed3m TLR2, TLR4, TLR5 v\u00e0 TLR6. Trong \u0111\u00f3, TLR4 v\u00e0 TLR5 ho\u1ea1t \u0111\u1ed9ng \u0111\u1ed9c l\u1eadp. TLR4 \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh c\u00f3 kh\u1ea3 n\u0103ng nh\u1eadn di\u1ec7n lipopolysaccharide (LPS) c\u1ee7a c\u00e1c vi khu\u1ea9n gram \u00e2m, \u0111\u1ed9c t\u1ed1 taxol \u1edf th\u1ef1c v\u1eadt, F protein c\u1ee7a virus g\u00e2y b\u1ec7nh h\u00f4 h\u1ea5p RSV v\u00e0 m\u1ed9t s\u1ed1 protein c\u1ee7a ch\u00ednh c\u01a1 th\u1ec3 v\u1eadt ch\u1ee7 nh\u01b0 HSP60 v\u00e0 fibronectin. TLR5 chuy\u00ean nh\u1eadn di\u1ec7n kh\u00e1ng nguy\u00ean ti\u00eam mao (Flagellin). Ng\u01b0\u1ee3c l\u1ea1i, TLR2 v\u00e0 TLR6 lu\u00f4n b\u1eaft c\u1eb7p v\u1edbi nhau \u0111\u1ec3 h\u1ee3p th\u00e0nh m\u1ed9t lo\u1ea1i th\u1ee5 th\u1ec3 c\u00f3 kh\u1ea3 n\u0103ng nh\u1eadn di\u1ec7n LPS c\u1ee7a m\u1ed9t s\u1ed1 vi khu\u1ea9n nh\u01b0 xo\u1eafn khu\u1ea9n Leptospira, vi khu\u1ea9n gram \u00e2m y\u1ebfm kh\u00ed Porphyromonas gingivalis, c\u00e1c lipoprotein, th\u00e0nh ph\u1ea7n peptidoglycan c\u1ee7a vi khu\u1ea9n, zymosan trong m\u00e0ng t\u1ebf b\u00e0o n\u1ea5m men (yeast)\u2026<\/p>\n\n\n\n Qu\u00e1 tr\u00ecnh ho\u00e0n thi\u1ec7n c\u1ee7a c\u00e1c c\u01a1 ch\u1ebf \u0111\u1ec1 kh\u00e1ng v\u00e0 h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch sau sinh di\u1ec5n ra nhanh hay ch\u1eadm t\u00f9y thu\u1ed9c v\u00e0o nhi\u1ec1u y\u1ebfu t\u1ed1 kh\u00e1c nhau. Trong \u0111\u00f3, c\u00e1c y\u1ebfu t\u1ed1 quan tr\u1ecdng nh\u1ea5t l\u00e0 s\u1ef1 c\u00e2n b\u1eb1ng c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t, th\u1eddi gian v\u00e0 li\u1ec1u l\u01b0\u1ee3ng m\u00e0 nh\u1eefng vi sinh v\u1eadt c\u0169ng nh\u01b0 nh\u1eefng kh\u00e1ng nguy\u00ean m\u1edbi l\u1ea1, l\u1ea7n \u0111\u1ea7u \u0111i v\u00e0o trong \u0111\u01b0\u1eddng ti\u00eau h\u00f3a qua th\u1ee9c \u0103n v\u00e0 n\u01b0\u1edbc u\u1ed1ng. Nh\u1eefng ng\u00e0y \u0111\u1ea7u ti\u00ean \u0111\u1ed1i v\u1edbi v\u1eadt nu\u00f4i, hay nh\u1eefng n\u0103m \u0111\u1ea7u ti\u00ean \u0111\u1ed1i v\u1edbi con ng\u01b0\u1eddi l\u00e0 th\u1eddi gian quan tr\u1ecdng nh\u1ea5t \u0111\u1ec3 h\u00ecnh th\u00e0nh \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch v\u00e0 th\u00f3i quen \u0103n u\u1ed1ng. Nh\u1eefng y\u1ebfu t\u1ed1 kh\u00e1c nh\u01b0 s\u1eefa m\u1eb9, s\u1eefa thay th\u1ebf hay vi\u1ec7c s\u1eed d\u1ee5ng kh\u00e1ng sinh, men ti\u00eau h\u00f3a c\u00f9ng c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c trong th\u1ee9c \u0103n n\u01b0\u1edbc u\u1ed1ng c\u0169ng g\u00f3p ph\u1ea7n \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 c\u00e2n b\u1eb1ng c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t, t\u00ednh to\u00e0n v\u1eb9n c\u1ee7a bi\u1ec3u m\u00f4 \u0111\u01b0\u1eddng ti\u00eau h\u00f3a v\u00e0 t\u00ednh ho\u00e0n thi\u1ec7n c\u1ee7a \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch.<\/p>\n\n\n\n Bi\u00ean so\u1ea1n: TS. BSTY. \u0110inh Xu\u00e2n Ph\u00e1t<\/em><\/p>\n","protected":false},"excerpt":{"rendered":" M\u1eb7c d\u00f9 tr\u1ebb hay th\u00fa s\u01a1 sinh m\u1ea1nh kh\u1ecfe \u0111\u1ec1u c\u00f3 m\u1ed9t h\u1ec7 mi\u1ec5n d\u1ecbch \u2018c\u00f3 n\u0103ng l\u1ef1c \u0111\u1ea7y \u0111\u1ee7\u2019 (competent) \u0111\u1ec3 thi\u1ebft l\u1eadp m\u1ed9t \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch \u0111\u1ea7y \u0111\u1ee7 \u0111\u1ed1i v\u1edbi m\u1ed9t kh\u00e1ng nguy\u00ean l\u1ea1 hay vacxin. Tuy nhi\u00ean, v\u1ec1 c\u01a1 ch\u1ebf h\u00ecnh th\u00e0nh \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch th\u00ec c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t r\u00f5 r\u1ec7t gi\u1eefa th\u00fa non v\u00e0 th\u00fa tr\u01b0\u1edfng th\u00e0nh, v\u00ec ba y\u1ebfu t\u1ed1 ch\u00ednh.<\/p>\n","protected":false},"author":4,"featured_media":8012,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"footnotes":""},"categories":[3,2],"tags":[39,55,32,56,54],"class_list":["post-8014","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-chan-nuoi","category-sinh-hoc","tag-che-pham-sinh-hoc","tag-men-tieu-hoa","tag-men-vi-sinh","tag-mien-dich","tag-proobiotic"],"yoast_head":"\n3.2. Mi\u1ec5n d\u1ecbch th\u1ec3 d\u1ecbch<\/strong><\/h4>\n\n\n\n
<\/figure><\/div>\n\n\n\n<\/figure><\/div>\n\n\n\n