{"id":8010,"date":"2019-02-27T11:14:05","date_gmt":"2019-02-27T04:14:05","guid":{"rendered":"https:\/\/biotekco.vn\/?p=8010"},"modified":"2019-02-27T11:14:07","modified_gmt":"2019-02-27T04:14:07","slug":"vai-tro-cua-he-vi-sinh-duong-ruot-doi-voi-he-mien-dich-p1","status":"publish","type":"post","link":"https:\/\/hhbio.vn\/?p=8010","title":{"rendered":"Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P1"},"content":{"rendered":"\n<h5 class=\"wp-block-heading\"><strong>Gi\u1edbi thi\u1ec7u<\/strong><\/h5>\n\n\n\n<p>H\u1ec7 mi\u1ec5n d\u1ecbch c\u1ee7a b\u00e0o thai tr\u00ean ng\u01b0\u1eddi c\u0169ng nh\u01b0 tr\u00ean th\u00fa l\u00fac \u0111\u1ea7u ph\u00e1t tri\u1ec3n m\u1ea1nh m\u1ebd \u1edf gan v\u00e0 l\u00e1ch, nh\u01b0ng thai c\u00e0ng l\u1edbn th\u00ec ch\u1ee9c n\u0103ng mi\u1ec5n d\u1ecbch t\u1ea1m th\u1eddi \u1edf c\u00e1c c\u01a1 quan n\u00e0y c\u00e0ng gi\u1ea3m d\u1ea7n \u0111\u1ec3 chu\u1ea9n b\u1ecb chuy\u1ec3n \u0111\u1ed5i ch\u1ee9c n\u0103ng mi\u1ec5n d\u1ecbch sang t\u1ee7y x\u01b0\u01a1ng \u1edf giai \u0111o\u1ea1n sau sinh. V\u00ec th\u1ebf nh\u1eefng ng\u00e0y \u0111\u00e2u ti\u00ean sau sinh l\u00e0 th\u1eddi gian h\u1ec7 mi\u1ec5n d\u1ecbch c\u1ee7a c\u01a1 th\u1ec3 y\u1ebfu nh\u1ea5t v\u00e0 tr\u1ebb em ho\u1eb7c th\u00fa s\u01a1 sinh c\u00f3 nguy c\u01a1 m\u1eabn c\u1ea3m nh\u1ea5t v\u1edbi c\u00e1c vi\u00eam nhi\u1ec5m.&nbsp;H\u1ec7 mi\u1ec5n d\u1ecbch c\u1ee7a b\u00e0o thai c\u0169ng c\u00f3 c\u01a1 ch\u1ebf t\u1ef1 ki\u1ec3m so\u00e1t v\u00e0 h\u1ea1n ch\u1ebf t\u1ed1i \u0111a vi\u1ec7c s\u1ea3n xu\u1ea5t c\u00e1c cytokine k\u00edch vi\u00eam v\u1edbi m\u1ee5c \u0111\u00edch tr\u01b0\u1edbc h\u1ebft l\u00e0 \u0111\u1ec3 ng\u0103n ng\u1eeba ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch gi\u1eefa c\u01a1 th\u1ec3 m\u1eb9 v\u00e0 b\u00e0o thai. \u0110i\u1ec1u n\u00e0y c\u00f3 \u0111i\u1ec3m b\u1ea5t l\u1ee3i l\u00e0 c\u01a1 th\u1ec3 b\u00e0o thai \u00edt \u0111\u01b0\u1ee3c b\u1ea3o v\u1ec7 n\u00ean s\u1ebd m\u1eabn c\u1ea3m v\u1edbi s\u1ef1 vi\u00eam nhi\u1ec5m c\u1ee7a t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh. B\u00e0o thai ho\u1eb7c th\u00fa con b\u1ecb vi\u00eam nhi\u1ec5m qu\u00e1 s\u1edbm tr\u01b0\u1edbc khi c\u00f3 s\u1ef1 tr\u01b0\u1edfng th\u00e0nh c\u1ee7a c\u00e1c c\u01a1 quan mi\u1ec5n d\u1ecbch g\u00f3p ph\u1ea7n l\u00e0m cho h\u1ec7 mi\u1ec5n d\u1ecbch l\u1ea7m t\u01b0\u1edfng nh\u1eefng vi sinh v\u1eadt g\u00e2y b\u1ec7nh \u0111\u00f3 l\u00e0 quen thu\u1ed9c v\u00e0 v\u00f4 h\u1ea1i v\u1edbi c\u01a1 th\u1ec3 n\u00ean kh\u00f4ng c\u00f2n thi\u1ebft l\u1eadp \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch v\u1edbi ch\u00fang n\u1eefa.&nbsp;Hi\u1ec7n t\u01b0\u1ee3ng n\u00e0y g\u1ecdi l\u00e0 s\u1ef1 dung n\u1ea1p mi\u1ec5n d\u1ecbch, kh\u00f4ng c\u00f3 l\u1ee3i cho s\u1ee9c kh\u1ecfe c\u1ee7a th\u00fa sau n\u00e0y. Do \u0111\u00f3, s\u1ef1 ti\u1ebfp x\u00fac c\u1ee7a th\u00fa s\u01a1 sinh v\u1edbi vi sinh v\u1eadt g\u00e2y b\u1ec7nh \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch c\u0169ng nh\u01b0 g\u00f3p ph\u1ea7n quy\u1ebft \u0111\u1ecbnh n\u0103ng su\u1ea5t c\u1ee7a th\u00fa trong t\u01b0\u01a1ng lai.&nbsp;H\u00e0ng ng\u00e0n lo\u00e0i vi khu\u1ea9n kh\u00e1c nhau c\u00f9ng sinh s\u1ed1ng trong \u0111\u01b0\u1eddng ru\u1ed9t c\u1ee7a m\u1ed9t c\u00e1 th\u1ec3 tr\u01b0\u1edfng th\u00e0nh (Noverr v\u00e0 Huffnagle, 2004) v\u1edbi s\u1ed1 l\u01b0\u1ee3ng l\u00ean \u0111\u1ebfn 10<sup>14<\/sup>&nbsp;t\u1ebf b\u00e0o vi khu\u1ea9n (Pickard et al., 2004). Con s\u1ed1 n\u00e0y l\u1edbn g\u1ea5p 10 l\u1ea7n t\u1ed5ng s\u1ed1 t\u1ebf b\u00e0o hi\u1ec7n di\u1ec7n trong m\u1ed9t con v\u1eadt hay con ng\u01b0\u1eddi \u1edf tu\u1ed5i tr\u01b0\u1edfng th\u00e0nh.&nbsp;<em><strong>H\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t ch\u00ednh l\u00e0 m\u1ed9t h\u1ec7 sinh th\u00e1i \u0111\u1eb7c th\u00f9, s\u1ed1ng \u0111\u1ed9ng v\u00e0 l\u00e0 m\u1ed9t h\u1ec7 th\u1ed1ng bi\u1ebfn d\u01b0\u1ee1ng quan tr\u1ecdng cung c\u1ea5p cho c\u01a1 th\u1ec3 v\u1eadt ch\u1ee7 nh\u1eefng c\u01a1 ch\u1ea5t c\u1ea7n thi\u1ebft. N\u00f3 c\u00f2n l\u00e0 h\u00e0ng r\u00e0o b\u1ea3o v\u1ec7 ng\u0103n ch\u1eb7n s\u1ef1 x\u00e2m nh\u1eadp c\u1ee7a t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh qua ni\u00eam m\u1ea1c ru\u1ed9t.<\/strong><\/em>&nbsp;Ngo\u00e0i ra, h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t c\u0169ng g\u00f3p ph\u1ea7n \u0111\u1ecbnh h\u00ecnh h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch, h\u00ecnh th\u00e1i c\u1ee7a \u0111\u01b0\u1ee3ng ru\u1ed9t, h\u1ed7 tr\u1ee3 ch\u1ee9c n\u0103ng c\u1ee7a h\u1ec7 ti\u00eau h\u00f3a v\u00e0 ngay c\u1ea3 l\u00e0 \u0111i\u1ec1u h\u00f2a bi\u1ec3u hi\u1ec7n gen c\u1ee7a v\u1eadt ch\u1ee7.&nbsp;B\u00e0i vi\u1ebft n\u00e0y t\u1eadp trung th\u1ea3o lu\u1eadn c\u00e1c y\u1ebfu t\u1ed1 \u1edf giai \u0111o\u1ea1n s\u01a1 sinh \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch m\u00e0ng nh\u1ea7y ru\u1ed9t. \u0110\u01b0\u1eddng ti\u00eau h\u00f3a l\u00e0 n\u01a1i t\u1eadp trung s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch d\u00e0y \u0111\u1eb7c nh\u1ea5t, c\u0169ng nh\u01b0 l\u00e0 n\u01a1i c\u00f3 s\u1ed1 l\u01b0\u1ee3ng vi sinh v\u1eadt \u0111\u00f4ng \u0111\u1ea3o nh\u1ea5t trong c\u01a1 th\u1ec3.<\/p>\n\n\n\n<h6 class=\"wp-block-heading\"><strong>Ho\u1ea1t \u0111\u1ed9ng c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch trong \u0111\u01b0\u1eddng ru\u1ed9t<\/strong><\/h6>\n\n\n\n<p>B\u00ean c\u1ea1nh c\u00e1c c\u01a1 quan mi\u1ec5n d\u1ecbch trung \u01b0\u01a1ng (t\u1ee7y x\u01b0\u01a1ng) v\u00e0 c\u01a1 quan mi\u1ec5n d\u1ecbch ngo\u1ea1i vi (l\u00e1ch, tuy\u1ebfn \u1ee9c, h\u1ea1ch b\u1ea1ch huy\u1ebft), c\u01a1 th\u1ec3 c\u00f2n thi\u1ebft k\u1ebf nh\u1eefng m\u1ea3ng b\u1ea1ch huy\u1ebft ch\u1ea1y d\u1ecdc theo h\u1ec7 th\u1ed1ng \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, d\u00e0y \u0111\u1eb7c nh\u1ea5t \u1edf \u0111\u01b0\u1eddng ru\u1ed9t, nh\u1ea5t l\u00e0 v\u00f9ng ru\u1ed9t gi\u00e0, g\u1ecdi l\u00e0 m\u00f4 lympho li\u00ean k\u1ebft ru\u1ed9t (GALT). GALT th\u01b0\u1eddng \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn h\u01a1n v\u1edbi t\u00ean g\u1ecdi \u2018m\u1ea3ng Peyer\u2019. Ho\u1ea1t \u0111\u1ed9ng c\u1ee7a m\u1ea3ng Peyer c\u00f3 li\u00ean quan ch\u1eb7t ch\u1ebd v\u1edbi t\u1ebf b\u00e0o M tr\u00ean bi\u1ec3u m\u00f4 ru\u1ed9t. T\u1ebf b\u00e0o M ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t c\u00e1i b\u1eaby \u0111\u1ec3 b\u1eaft gi\u1eef vi sinh v\u1eadt, kh\u00e1ng nguy\u00ean h\u00f2a tan hay \u1edf d\u1ea1ng c\u00e1c h\u1ea1t nh\u1ecf v\u00e0 v\u1eadn chuy\u1ec3n ch\u00fang m\u1ed9t c\u00e1ch t\u00edch c\u1ef1c t\u1eeb l\u00f2ng ru\u1ed9t v\u00e0o trong c\u00e1c m\u00f4 lympho c\u1ee7a m\u1ea3ng Peyer (H\u00ecnh 1).\u00a0Nh\u1edd \u0111\u00f3, c\u00e1c t\u1ebf b\u00e0o lympho B v\u00e0 T c\u0169ng nh\u01b0 c\u00e1c t\u1ebf b\u00e0o kh\u00e1c c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch \u0111\u01b0\u1ee3c g\u1eb7p m\u1eb7t v\u1edbi r\u1ea5t nhi\u1ec1u lo\u1ea1i kh\u00e1ng nguy\u00ean hi\u1ec7n di\u1ec7n trong \u0111\u01b0\u1eddng ru\u1ed9t. Tuy nhi\u00ean c\u0169ng c\u00f3 m\u1ed9t s\u1ed1 vi sinh v\u1eadt, l\u1ee3i d\u1ee5ng t\u1ebf b\u00e0o M \u0111\u1ec3 x\u00e2m nh\u1eadp v\u00e0o trong m\u00f4 ru\u1ed9t, sau \u0111\u00f3 ph\u00e1t t\u00e1n \u0111\u1ebfn nh\u1eefng c\u01a1 quan kh\u00e1c c\u1ee7a c\u01a1 th\u1ec3.\u00a0<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" width=\"966\" height=\"530\" src=\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/image001.jpg\" alt=\"\" class=\"wp-image-8011\" srcset=\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/image001.jpg 966w, https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/image001-300x165.jpg 300w, https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/image001-768x421.jpg 768w\" sizes=\"(max-width: 966px) 100vw, 966px\" \/><\/figure>\n\n\n\n<p>H\u00ecnh 1 minh h\u1ecda c\u1ea5u tr\u00fac v\u00e0 v\u1ecb tr\u00ed c\u1ee7a c\u00e1c th\u00e0nh ph\u1ea7n c\u00f3 trong l\u00f2ng v\u00e0 th\u00e0nh ru\u1ed9t. H\u1ec7 vi khu\u1ea9n t\u1ed3n t\u1ea1i trong d\u01b0\u1ee1ng tr\u1ea5p (ch\u1ea5t ch\u1ee9a trong l\u00f2ng ru\u1ed9t) v\u00e0 trong l\u1edbp ch\u1ea5t nh\u1ea7y do c\u00e1c t\u1ebf b\u00e0o trong l\u1edbp bi\u1ec3u m\u00f4 ti\u1ebft ra. L\u1edbp ch\u1ea5t nh\u1ea7y v\u1eeba l\u00e0 ngu\u1ed3n th\u1ee9c \u0103n, v\u1eeba l\u00e0 n\u01a1i tr\u00fa ng\u1ee5 cho c\u00e1c vi sinh v\u1eadt, \u0111\u1ed3ng th\u1eddi l\u00e0 l\u1edbp b\u1ea3o v\u1ec7 cho l\u1edbp t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 b\u00ean d\u01b0\u1edbi. C\u1ea5u tr\u00fac l\u1edbp bi\u1ec3u m\u00f4 c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa ru\u1ed9t non (t\u00e1 tr\u00e0ng, kh\u00f4ng tr\u00e0ng, h\u1ed3i tr\u00e0ng) v\u00e0 ru\u1ed9t gi\u00e0 (manh tr\u00e0ng, k\u1ebft tr\u00e0ng, tr\u1ef1c tr\u00e0ng). T\u1ebf b\u00e0o M (microfold cell, M cells) v\u00e0 Paneth (t\u1ebf b\u00e0o ti\u1ebft enzyme) ch\u1ec9 c\u00f3 m\u1eb7t \u1edf ru\u1ed9t non.\u00a0T\u1ebf b\u00e0o M l\u00e0m nhi\u1ec7m v\u1ee5 b\u1eaft gi\u1eef v\u00e0 v\u1eadn chuy\u1ec3n c\u00e1c vi sinh v\u1eadt t\u1eeb l\u00f2ng ru\u1ed9t v\u00e0o trong c\u00e1c t\u1ed5 ch\u1ee9c lympho b\u00ean d\u01b0\u1edbi l\u1edbp bi\u1ec3u m\u00f4 \u0111\u1ec3 chuy\u1ec3n giao k\u1ecbp th\u1eddi nh\u1eefng t\u00e1c nh\u00e2n l\u1ea1 xu\u1ea5t hi\u1ec7n trong l\u00f2ng ru\u1ed9t cho c\u00e1c t\u1ebf b\u00e0o tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean (t\u1ebf b\u00e0o tua, \u0111\u1ea1i th\u1ef1c b\u00e0o) v\u00e0 c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch c\u00f3 th\u1ea9m quy\u1ec1n mi\u1ec5n d\u1ecbch kh\u00e1c (lympho T, B). \u0110\u1ec3 hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 ho\u1ea1t \u0111\u1ed9ng mi\u1ec5n d\u1ecbch c\u1ee7a t\u1ebf b\u00e0o M, xin tham kh\u1ea3o trong c\u00e1c ch\u01b0\u01a1ng Mi\u1ec5n d\u1ecbch h\u1ecdc.\u00a0C\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch hi\u1ec7n di\u1ec7n trong m\u00f4 ru\u1ed9t, trong c\u00e1c m\u00f4 lympho c\u1ee7a ru\u1ed9t (m\u1ea3ng Peyer\u2019s \u1edf ru\u1ed9t non), c\u00e1c nang lympho, c\u00e1c d\u1ea3i lympho k\u1ebft tr\u00e0ng (colonic patches) c\u00f3 nhi\u1ec7m v\u1ee5 r\u00e0 so\u00e1t c\u0169ng nh\u01b0 quy\u1ebft \u0111\u1ecbnh dung n\u1ea1p (\u0111\u1ed1i v\u1edbi c\u00e1c vi khu\u1ea9n c\u00f3 l\u1ee3i) hay t\u1ea5n c\u00f4ng ch\u1ed1ng l\u1ea1i s\u1ef1 x\u00e2m nh\u1eadp c\u1ee7a nh\u1eefng t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh. \u0110\u1ec3 th\u1ef1c hi\u1ec7n \u0111\u01b0\u1ee3c ch\u1ee9c n\u0103ng n\u00e0y, c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch \u1edf \u0111\u00e2y c\u1ea7n ph\u1ea3i ph\u00e2n bi\u1ec7t \u0111\u01b0\u1ee3c c\u00e1c vi khu\u1ea9n c\u00f3 l\u1ee3i thu\u1ed9c h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t hay c\u00e1c vi tr\u00f9ng g\u00e2y b\u1ec7nh kh\u00e1c.\u00a0\u0110a s\u1ed1 c\u00e1c kh\u00e1ng nguy\u00ean l\u1ea1 xu\u1ea5t hi\u1ec7n trong \u0111\u01b0\u1eddng ru\u1ed9t c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb th\u1ee9c \u0103n v\u00e0 n\u01b0\u1edbc u\u1ed1ng. C\u00f2n c\u00e1c vi khu\u1ea9n c\u00f3 l\u1ee3i \u0111\u01b0\u1eddng ru\u1ed9t (micro flora ho\u1eb7c microbiota) th\u00ec khu tr\u00fa l\u00e2u d\u00e0i v\u00e0 kh\u00f4ng k\u00edch th\u00edch c\u01a1 th\u1ec3 s\u1ea3n sinh \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch \u0111\u1eb7c hi\u1ec7u ch\u1ed1ng l\u1ea1i ch\u00fang, hi\u1ec7n t\u01b0\u1ee3ng n\u00e0y \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 \u2018s\u1ef1 dung n\u1ea1p qua \u0111\u01b0\u1eddng mi\u1ec7ng\u2019 (oral tolerance). C\u01a1 ch\u1ebf ch\u00ednh x\u00e1c c\u1ee7a hi\u1ec7n t\u01b0\u1ee3ng dung n\u1ea1p qua \u0111\u01b0\u1eddng mi\u1ec7ng ch\u01b0a \u0111\u01b0\u1ee3c th\u1ed1ng nh\u1ea5t \u00fd ki\u1ebfn. Nh\u01b0ng ng\u01b0\u1eddi ta cho r\u1eb1ng n\u00f3 li\u00ean quan \u0111\u1ebfn s\u1ef1 t\u01b0\u01a1ng t\u00e1c qua l\u1ea1i gi\u1eefa h\u1ec7 vi sinh v\u1edbi bi\u1ec3u m\u00f4 v\u00e0 m\u00f4 lympho d\u1ecdc theo \u0111\u01b0\u1eddng ru\u1ed9t, b\u1eaft \u0111\u1ea7u t\u1eeb khi thai \u0111\u01b0\u1ee3c sinh ra.\u00a0Nh\u01b0 v\u1eady, m\u1ea3ng Peyer cung c\u1ea5p kh\u1ea3 n\u0103ng ph\u00f2ng h\u1ed9 ch\u1ed1ng l\u1ea1i c\u00e1c t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh x\u00e2m nh\u1eadp qua \u0111\u01b0\u1eddng ru\u1ed9t, c\u00f2n \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch \u0111\u1ed1i v\u1edbi c\u00e1c vi sinh v\u1eadt kh\u00f4ng g\u00e2y h\u1ea1i kh\u00f4ng \u0111\u01b0\u1ee3c h\u00ecnh th\u00e0nh.\u00a0\u0110\u1ec3 hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 c\u00e1c lo\u1ea1i vi sinh c\u00f3 l\u1ee3i \u0111\u01b0\u1eddng ru\u1ed9t, xin tham kh\u1ea3o ph\u1ea7n \u2018H\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t\u2019.<\/p>\n\n\n\n<p><em>Bi\u00ean so\u1ea1n: TS. BSTY. \u0110inh Xu\u00e2n Ph\u00e1t<\/em><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>. H\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t ch\u00ednh l\u00e0 m\u1ed9t h\u1ec7 sinh th\u00e1i \u0111\u1eb7c th\u00f9, s\u1ed1ng \u0111\u1ed9ng v\u00e0 l\u00e0 m\u1ed9t h\u1ec7 th\u1ed1ng bi\u1ebfn d\u01b0\u1ee1ng quan tr\u1ecdng cung c\u1ea5p cho c\u01a1 th\u1ec3 v\u1eadt ch\u1ee7 nh\u1eefng c\u01a1 ch\u1ea5t c\u1ea7n thi\u1ebft. N\u00f3 c\u00f2n l\u00e0 h\u00e0ng r\u00e0o b\u1ea3o v\u1ec7 ng\u0103n ch\u1eb7n s\u1ef1 x\u00e2m nh\u1eadp c\u1ee7a t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh qua ni\u00eam m\u1ea1c ru\u1ed9t.<\/p>\n","protected":false},"author":4,"featured_media":8012,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"footnotes":""},"categories":[3,2],"tags":[55,32,56,54,53],"class_list":["post-8010","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-chan-nuoi","category-sinh-hoc","tag-men-tieu-hoa","tag-men-vi-sinh","tag-mien-dich","tag-proobiotic","tag-vi-sinh-duong-ruot"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.11 (Yoast SEO v25.5) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P1 - H\u1ea3i H\u01b0ng Probiotics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hhbio.vn\/?p=8010\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P1\" \/>\n<meta property=\"og:description\" content=\". H\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t ch\u00ednh l\u00e0 m\u1ed9t h\u1ec7 sinh th\u00e1i \u0111\u1eb7c th\u00f9, s\u1ed1ng \u0111\u1ed9ng v\u00e0 l\u00e0 m\u1ed9t h\u1ec7 th\u1ed1ng bi\u1ebfn d\u01b0\u1ee1ng quan tr\u1ecdng cung c\u1ea5p cho c\u01a1 th\u1ec3 v\u1eadt ch\u1ee7 nh\u1eefng c\u01a1 ch\u1ea5t c\u1ea7n thi\u1ebft. N\u00f3 c\u00f2n l\u00e0 h\u00e0ng r\u00e0o b\u1ea3o v\u1ec7 ng\u0103n ch\u1eb7n s\u1ef1 x\u00e2m nh\u1eadp c\u1ee7a t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh qua ni\u00eam m\u1ea1c ru\u1ed9t.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hhbio.vn\/?p=8010\" \/>\n<meta property=\"og:site_name\" content=\"H\u1ea3i H\u01b0ng Probiotics\" \/>\n<meta property=\"article:published_time\" content=\"2019-02-27T04:14:05+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-02-27T04:14:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"445\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"10 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/hhbio.vn\/?p=8010#article\",\"isPartOf\":{\"@id\":\"https:\/\/hhbio.vn\/?p=8010\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/hhbio.vn\/#\/schema\/person\/39485024c55ecf320ea3302bad2b6ef4\"},\"headline\":\"Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P1\",\"datePublished\":\"2019-02-27T04:14:05+00:00\",\"dateModified\":\"2019-02-27T04:14:07+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/hhbio.vn\/?p=8010\"},\"wordCount\":1925,\"publisher\":{\"@id\":\"https:\/\/hhbio.vn\/#organization\"},\"image\":{\"@id\":\"https:\/\/hhbio.vn\/?p=8010#primaryimage\"},\"thumbnailUrl\":\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg\",\"keywords\":[\"men ti\u00eau h\u00f3a\",\"men vi sinh\",\"mi\u1ec5n d\u1ecbch\",\"proobiotic\",\"vi sinh \u0111\u01b0\u1eddng ru\u1ed9t\"],\"articleSection\":[\"Ch\u0103n nu\u00f4i\",\"Sinh h\u1ecdc\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/hhbio.vn\/?p=8010\",\"url\":\"https:\/\/hhbio.vn\/?p=8010\",\"name\":\"Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P1 - H\u1ea3i H\u01b0ng Probiotics\",\"isPartOf\":{\"@id\":\"https:\/\/hhbio.vn\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/hhbio.vn\/?p=8010#primaryimage\"},\"image\":{\"@id\":\"https:\/\/hhbio.vn\/?p=8010#primaryimage\"},\"thumbnailUrl\":\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg\",\"datePublished\":\"2019-02-27T04:14:05+00:00\",\"dateModified\":\"2019-02-27T04:14:07+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/hhbio.vn\/?p=8010#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/hhbio.vn\/?p=8010\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/hhbio.vn\/?p=8010#primaryimage\",\"url\":\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg\",\"contentUrl\":\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg\",\"width\":800,\"height\":445},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/hhbio.vn\/?p=8010#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/hhbio.vn\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P1\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/hhbio.vn\/#website\",\"url\":\"https:\/\/hhbio.vn\/\",\"name\":\"BIOTEKCO\",\"description\":\"Building Products For You\",\"publisher\":{\"@id\":\"https:\/\/hhbio.vn\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/hhbio.vn\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/hhbio.vn\/#organization\",\"name\":\"BIOTEKCO.,LTD\",\"url\":\"https:\/\/hhbio.vn\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/hhbio.vn\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/01\/logo-cmyk-01-1-e1560779045791.png\",\"contentUrl\":\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/01\/logo-cmyk-01-1-e1560779045791.png\",\"width\":216,\"height\":90,\"caption\":\"BIOTEKCO.,LTD\"},\"image\":{\"@id\":\"https:\/\/hhbio.vn\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/hhbio.vn\/#\/schema\/person\/39485024c55ecf320ea3302bad2b6ef4\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/hhbio.vn\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/60ff287c3f4ad60471147e6035b7a6ab4e48cf6d5733f6bc839ca2a2caee08df?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/60ff287c3f4ad60471147e6035b7a6ab4e48cf6d5733f6bc839ca2a2caee08df?s=96&d=mm&r=g\",\"caption\":\"admin\"}}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P1 - H\u1ea3i H\u01b0ng Probiotics","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/hhbio.vn\/?p=8010","og_locale":"en_US","og_type":"article","og_title":"Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P1","og_description":". H\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t ch\u00ednh l\u00e0 m\u1ed9t h\u1ec7 sinh th\u00e1i \u0111\u1eb7c th\u00f9, s\u1ed1ng \u0111\u1ed9ng v\u00e0 l\u00e0 m\u1ed9t h\u1ec7 th\u1ed1ng bi\u1ebfn d\u01b0\u1ee1ng quan tr\u1ecdng cung c\u1ea5p cho c\u01a1 th\u1ec3 v\u1eadt ch\u1ee7 nh\u1eefng c\u01a1 ch\u1ea5t c\u1ea7n thi\u1ebft. N\u00f3 c\u00f2n l\u00e0 h\u00e0ng r\u00e0o b\u1ea3o v\u1ec7 ng\u0103n ch\u1eb7n s\u1ef1 x\u00e2m nh\u1eadp c\u1ee7a t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh qua ni\u00eam m\u1ea1c ru\u1ed9t.","og_url":"https:\/\/hhbio.vn\/?p=8010","og_site_name":"H\u1ea3i H\u01b0ng Probiotics","article_published_time":"2019-02-27T04:14:05+00:00","article_modified_time":"2019-02-27T04:14:07+00:00","og_image":[{"width":800,"height":445,"url":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg","type":"image\/jpeg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Written by":"admin","Est. reading time":"10 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/hhbio.vn\/?p=8010#article","isPartOf":{"@id":"https:\/\/hhbio.vn\/?p=8010"},"author":{"name":"admin","@id":"https:\/\/hhbio.vn\/#\/schema\/person\/39485024c55ecf320ea3302bad2b6ef4"},"headline":"Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P1","datePublished":"2019-02-27T04:14:05+00:00","dateModified":"2019-02-27T04:14:07+00:00","mainEntityOfPage":{"@id":"https:\/\/hhbio.vn\/?p=8010"},"wordCount":1925,"publisher":{"@id":"https:\/\/hhbio.vn\/#organization"},"image":{"@id":"https:\/\/hhbio.vn\/?p=8010#primaryimage"},"thumbnailUrl":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg","keywords":["men ti\u00eau h\u00f3a","men vi sinh","mi\u1ec5n d\u1ecbch","proobiotic","vi sinh \u0111\u01b0\u1eddng ru\u1ed9t"],"articleSection":["Ch\u0103n nu\u00f4i","Sinh h\u1ecdc"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/hhbio.vn\/?p=8010","url":"https:\/\/hhbio.vn\/?p=8010","name":"Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P1 - H\u1ea3i H\u01b0ng Probiotics","isPartOf":{"@id":"https:\/\/hhbio.vn\/#website"},"primaryImageOfPage":{"@id":"https:\/\/hhbio.vn\/?p=8010#primaryimage"},"image":{"@id":"https:\/\/hhbio.vn\/?p=8010#primaryimage"},"thumbnailUrl":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg","datePublished":"2019-02-27T04:14:05+00:00","dateModified":"2019-02-27T04:14:07+00:00","breadcrumb":{"@id":"https:\/\/hhbio.vn\/?p=8010#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/hhbio.vn\/?p=8010"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/hhbio.vn\/?p=8010#primaryimage","url":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg","contentUrl":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/khuan-duong-ruot.jpg","width":800,"height":445},{"@type":"BreadcrumbList","@id":"https:\/\/hhbio.vn\/?p=8010#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/hhbio.vn\/"},{"@type":"ListItem","position":2,"name":"Vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch-P1"}]},{"@type":"WebSite","@id":"https:\/\/hhbio.vn\/#website","url":"https:\/\/hhbio.vn\/","name":"BIOTEKCO","description":"Building Products For You","publisher":{"@id":"https:\/\/hhbio.vn\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/hhbio.vn\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/hhbio.vn\/#organization","name":"BIOTEKCO.,LTD","url":"https:\/\/hhbio.vn\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/hhbio.vn\/#\/schema\/logo\/image\/","url":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/01\/logo-cmyk-01-1-e1560779045791.png","contentUrl":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/01\/logo-cmyk-01-1-e1560779045791.png","width":216,"height":90,"caption":"BIOTEKCO.,LTD"},"image":{"@id":"https:\/\/hhbio.vn\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/hhbio.vn\/#\/schema\/person\/39485024c55ecf320ea3302bad2b6ef4","name":"admin","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/hhbio.vn\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/60ff287c3f4ad60471147e6035b7a6ab4e48cf6d5733f6bc839ca2a2caee08df?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/60ff287c3f4ad60471147e6035b7a6ab4e48cf6d5733f6bc839ca2a2caee08df?s=96&d=mm&r=g","caption":"admin"}}]}},"_links":{"self":[{"href":"https:\/\/hhbio.vn\/index.php?rest_route=\/wp\/v2\/posts\/8010","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hhbio.vn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hhbio.vn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hhbio.vn\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/hhbio.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8010"}],"version-history":[{"count":0,"href":"https:\/\/hhbio.vn\/index.php?rest_route=\/wp\/v2\/posts\/8010\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/hhbio.vn\/index.php?rest_route=\/wp\/v2\/media\/8012"}],"wp:attachment":[{"href":"https:\/\/hhbio.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8010"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hhbio.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=8010"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hhbio.vn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=8010"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}