{"id":7923,"date":"2019-02-25T15:17:22","date_gmt":"2019-02-25T08:17:22","guid":{"rendered":"https:\/\/biotekco.vn\/?p=7923"},"modified":"2019-06-25T22:09:49","modified_gmt":"2019-06-25T15:09:49","slug":"vi-khuan-co-loi-va-kiem-soat-mam-benh","status":"publish","type":"post","link":"https:\/\/hhbio.vn\/?p=7923","title":{"rendered":"Vi khu\u1ea9n c\u00f3 l\u1ee3i v\u00e0 ki\u1ec3m so\u00e1t m\u1ea7m b\u1ec7nh"},"content":{"rendered":"\n

Vi khu\u1ea9n g\u00e2y b\u1ec7nh ch\u00ednh l\u00e0 m\u1ed1i quan t\u00e2m ch\u00ednh trong ng\u00e0nh nu\u00f4i tr\u1ed3ng th\u1ee7y s\u1ea3n. H\u1ea7u h\u1ebft nh\u1eefng m\u1ea7m b\u1ec7nh n\u00e0y l\u00e0 vi khu\u1ea9n c\u01a1 h\u1ed9i, lu\u00f4n c\u00f3 m\u1eb7t h\u1ec7 vi sinh tr\u00ean b\u1ec1 m\u1eb7t v\u00e0 trong ru\u1ed9t \u0111\u1ed9ng v\u1eadt, v\u00e0 trong m\u00f4i tr\u01b0\u1eddng \u0111\u1ea5t v\u00e0 n\u01b0\u1edbc. Mi\u1ec5n l\u00e0 \u0111i\u1ec1u ki\u00ean n\u01b0\u1edbc, s\u1ee9c kh\u1ecfe \u0111\u1ed9ng v\u1eadt v\u00e0 h\u1ec7 vi sinh duy tr\u00ec \u1ed5n \u0111\u1ecbnh, kh\u1ea3 n\u0103ng m\u1ea7m b\u1ec7nh c\u01a1 h\u1ed9i g\u00e2y ra d\u1ecbch b\u1ec7nh r\u1ea5t th\u1ea5p.<\/p>\n\n\n\n

Tuy nhi\u00ean, khi c\u00e1c \u0111i\u1ec1u ki\u1ec7n bi\u1ebfn \u0111\u1ed9ng, ch\u1ea5t l\u01b0\u1ee3ng n\u01b0\u1edbc suy gi\u1ea3m, v\u00e0 s\u1ee9c kh\u1ecfe \u0111\u1ed9ng v\u1eadt b\u1ecb t\u1ed5n h\u1ea1i, c\u00e1c t\u00e1c nh\u00e2n c\u01a1 h\u1ed9i s\u1ebd n\u1eafm l\u1ea5y th\u1eddi c\u01a1, sinh s\u1ea3n r\u1ea5t nhanh v\u00e0 g\u00e2y ra b\u1ec7nh truy\u1ec1n nhi\u1ec5m. V\u00ec v\u1eady, \u0111\u1ec3 ki\u1ec3m so\u00e1t m\u1ea7m b\u1ec7nh c\u01a1 h\u1ed9i, duy tr\u00ec s\u1ef1 \u1ed5n \u0111\u1ecbnh c\u1ee7a m\u00f4i tr\u01b0\u1eddng v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng n\u01b0\u1edbc l\u00e0 v\u00f4 c\u00f9ng quan tr\u1ecdng.<\/p>\n\n\n\n

<\/p>\n\n\n\n

K\u0129 n\u0103ng qu\u1ea3n l\u00fd ao nu\u00f4i ch\u00ednh l\u00e0 \u0111i\u1ec1u ki\u1ec7n ti\u00ean quy\u1ebft. Ngo\u00e0i ra, c\u00f3 th\u1ec3 \u00e1p d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p s\u1eed d\u1ee5ng vaccine v\u00e0 kh\u00e1ng sinh nh\u01b0ng ch\u00fang c\u0169ng c\u00f3 nhi\u1ec1u nh\u01b0\u1ee3c \u0111i\u1ec3m. Vaccine v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u h\u1ebft cho m\u1ecdi lo\u00e0i v\u00e0 m\u1ecdi c\u0103n b\u1ec7nh. Ch\u1ec9 c\u00f3 vaccine cho m\u1ed9t v\u00e0i b\u1ec7nh, ch\u1ee7 y\u1ebfu l\u00e0 nh\u1eefng b\u1ec7nh truy\u1ec1n nhi\u1ec5m nhanh, v\u00e0 vaccine kh\u00f4ng th\u1ef1c s\u1ef1 hi\u1ec7u qu\u1ea3 cho t\u00f4m. Hi\u1ec7u qu\u1ea3 c\u1ee7a vaccine ph\u1ee5 thu\u1ed9c v\u00e0o nhi\u1ec1u y\u1ebfu t\u1ed1, ch\u1eb3ng h\u1ea1n nh\u01b0 t\u00ecnh tr\u1ea1ng mi\u1ec5n d\u1ecbch v\u00e0 k\u00edch th\u01b0\u1edbc \u0111\u1ed9ng v\u1eadt, l\u1ed9 tr\u00ecnh v\u00e0 ch\u1ebf \u0111\u1ed9 qu\u1ea3n l\u00fd. Ngo\u00e0i ra, vi\u1ec7c s\u1eed d\u1ee5ng vaccine r\u1ea5t t\u1ed1n k\u00e9m, t\u1ed1n nhi\u1ec1u c\u00f4ng s\u1ee9c v\u00e0 d\u1ec5 l\u00e0m \u0111\u1ed9ng v\u1eadt b\u1ecb c\u0103ng th\u1eb3ng.<\/p>\n\n\n\n

Tr\u01b0\u1edbc \u0111\u00e2y,\nkh\u00e1ng sinh th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 th\u00fac \u0111\u1ea9y t\u0103ng tr\u01b0\u1edfng c\u0169ng nh\u01b0 ph\u00f2ng ch\u1ed1ng b\u1ec7nh\nt\u1eadt. Tuy nhi\u00ean, vi\u1ec7c s\u1eed d\u1ee5ng kh\u00e1ng sinh kh\u00f4ng \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t \u0111\u00e3 d\u1eabn \u0111\u1ebfn s\u1ef1 gia\nt\u0103ng c\u00e1c ki\u1ec3u h\u00ecnh kh\u00e1ng thu\u1ed1c \u1edf c\u00e1c vi khu\u1ea9n g\u00e2y b\u1ec7nh. \u00c1p l\u1ef1c ch\u1ecdn l\u1ecdc\nli\u00ean t\u1ee5c kh\u00f4ng ch\u1ec9 k\u00edch ho\u1ea1t kh\u1ea3 n\u0103ng kh\u00e1ng thu\u1ed1c, m\u00e0 c\u00f2n truy\u1ec1n ch\u00fang v\u00e0o\nm\u00f4i tr\u01b0\u1eddng. Do \u0111\u00f3, vi\u1ec7c \u00e1p d\u1ee5ng kh\u00e1ng sinh nh\u01b0 l\u00e0 bi\u1ec7n ph\u00e1p ph\u00f2ng ng\u1eeba \u0111ang g\u00e2y\nr\u1ea5t nhi\u1ec1u tranh c\u00e3i.<\/p>\n\n\n\n

Ng\u00e0y nay, m\u1ed9t lo\u1ea1t c\u00e1c s\u1ea3n ph\u1ea9m thay th\u1ebf \u0111\u01b0\u1ee3c \u0111\u01b0a ra \u0111\u1ec3 c\u1ea3i thi\u1ec7n s\u1ee9c kh\u1ecfe \u0111\u1ed9ng v\u1eadt, ch\u1ea5t l\u01b0\u1ee3ng n\u01b0\u1edbc v\u00e0 ki\u1ec3m so\u00e1t t\u1ea3i l\u01b0\u1ee3ng m\u1ea7m b\u1ec7nh. Vi\u1ec7c s\u1eed d\u1ee5ng vi khu\u1ea9n c\u00f3 l\u1ee3i, ho\u1eb7c ch\u1ebf ph\u1ea9m sinh h\u1ecdc, l\u00e0 m\u1ed9t c\u00e1ch \u0111\u1ec3 duy tr\u00ec t\u00ecnh tr\u1ea1ng \u1ed5n \u0111\u1ecbnh v\u00e0 ng\u0103n ng\u1eeba m\u1ea7m b\u1ec7nh c\u01a1 h\u1ed9i x\u00e2m nh\u1eadp.<\/p>\n\n\n\n

Ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng n\u01b0\u1edbc<\/strong> <\/p>\n\n\n\n

Trong qu\u00e1 tr\u00ecnh nu\u00f4i tr\u1ed3ng th\u1ee7y s\u1ea3n, ph\u00e2n, n\u01b0\u1edbc ti\u1ec3u v\u00e0 th\u1ee9c \u0103n th\u1eeba \u0111\u01b0\u1ee3c th\u1ea3i v\u00e0o n\u01b0\u1edbc nu\u00f4i. Khi c\u00e1c v\u1eadt ch\u1ea5t h\u1eefu c\u01a1 n\u00e0y t\u00edch t\u1ee5, m\u1ee9c \u0111\u1ed9 c\u00e1c h\u1ee3p ch\u1ea5t \u0111\u1ed9c h\u1ea1i t\u0103ng l\u00ean v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng n\u01b0\u1edbc c\u0169ng theo \u0111\u00f3 suy gi\u1ea3m. V\u00ec v\u1eady, c\u00e1c ch\u1ea5t h\u1eefu c\u01a1 th\u1eeba v\u00e0 c\u00e1c ch\u1ea5t \u0111\u1ed9c h\u1ea1i c\u1ea7n ph\u1ea3i lo\u1ea1i b\u1ecf. Vi khu\u1ea9n c\u00f3 th\u1ec3 h\u1ed7 tr\u1ee3 qu\u00e1 tr\u00ecnh n\u00e0y. Vi\u1ec7c s\u1eed d\u1ee5ng th\u1ef1c v\u1eadt ho\u1eb7c vi sinh<\/a> v\u1eadt nh\u01b0 vi khu\u1ea9n \u0111\u1ec3 lo\u1ea1i b\u1ecf ch\u1ea5t th\u1ea3i \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 bioremediation<\/em> – x\u1eed l\u00fd \u00f4 nhi\u1ec5m sinh h\u1ecdc.<\/p>\n\n\n\n

S\u1ef1 d\u01b0 th\u1eeba c\u00e1c ch\u1ea5t h\u1eefu c\u01a1 cung c\u1ea5p c\u00e1c \u0111i\u1ec1u ki\u1ec7n t\u0103ng tr\u01b0\u1edfng tuy\u1ec7t v\u1eddi cho c\u00e1c m\u1ea7m b\u1ec7nh c\u01a1 h\u1ed9i v\u00e0 t\u1ea1o ti\u1ec1n \u0111\u1ec1 cho b\u1ec7nh truy\u1ec1n nhi\u1ec5m. C\u00e1c l\u1ee3i khu\u1ea9n nh\u01b0 c\u00e1c d\u00f2ng Bacillus<\/a><\/em> <\/a>kho\u00e1ng h\u00f3a c\u00e1c ch\u1ea5t h\u1eefu c\u01a1, do \u0111\u00f3 gi\u00fap c\u1eaft gi\u1ea3m g\u00e1nh n\u1eb7ng n\u00e0y.<\/p>\n\n\n\n

C\u00e1c h\u1ee3p ch\u1ea5t Nit\u01a1 nh\u01b0 ion Nitrit, Nitrat v\u00e0 Amoni c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb vi\u1ec7c ph\u00e2n h\u1ee7y d\u01b0 l\u01b0\u1ee3ng th\u1ee9c \u0103n v\u00e0 ch\u1ea5t th\u1ea3i c\u1ee7a \u0111\u1ed9ng v\u1eadt. Khi c\u00e1c h\u1ee3p ch\u1ea5t n\u00e0y v\u01b0\u1ee3t qu\u00e1 m\u1ee9c nh\u1ea5t \u0111\u1ecbnh, ch\u00fang tr\u1edf n\u00ean \u0111\u1ed9c h\u1ea1i. C\u00e1c ion Amoni g\u00e2y \u1ee9c ch\u1ebf th\u1ea7n kinh v\u00e0 vi\u1ec7c ti\u1ebfp x\u00fac k\u00e9o d\u00e0i v\u1edbi n\u1ed3ng \u0111\u1ed9 Nitrit t\u0103ng cao g\u00e2y ra ng\u1ea1t th\u1edf ch\u1eadm, \u0111\u1eb7c bi\u1ec7t l\u00e0 khi thi\u1ebfu Oxy. M\u1eb7c d\u00f9 kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng \u1edf n\u1ed3ng \u0111\u1ed9 th\u1ea5p, vi\u1ec7c ti\u1ebfp x\u00fac v\u1edbi Nitrat k\u00e9o d\u00e0i c\u00f3 th\u1ec3 g\u00e2y gi\u1ea3m c\u00e2n v\u00e0 khi\u1ebfn \u0111\u1ed9ng v\u1eadt d\u1ec5 m\u1eafc b\u1ec7nh truy\u1ec1n nhi\u1ec5m.<\/p>\n\n\n\n

\u0110\u1ec3 tr\u00e1nh c\u00e1c bi\u1ebfn ch\u1ee9ng nh\u01b0 v\u1eady, l\u1ee3i khu\u1ea9n \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o h\u1ec7 th\u1ed1ng nu\u00f4i c\u1ea5y. Nh\u1eefng lo\u00e0i n\u00e0y th\u1ef1c hi\u1ec7n qu\u00e1 tr\u00ecnh Nitrat h\u00f3a v\u00e0 \/ ho\u1eb7c kh\u1eed Nitrat (H\u00ecnh 1 v\u00e0 2) v\u00e0 do \u0111\u00f3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 Amoni, Nitrat v\u00e0 Nitrit trong n\u01b0\u1edbc. Nitrat h\u00f3a b\u1eb1ng vi khu\u1ea9n l\u00e0 qu\u00e1 tr\u00ecnh Oxy h\u00f3a Amoni th\u00e0nh Nitrat th\u00f4ng qua Hydroxyl amin v\u00e0 Nitrit. Qu\u00e1 tr\u00ecnh kh\u1eed Nitrat l\u00e0 kh\u1eed Nitrat th\u00e0nh Nit\u01a1 Oxit v\u00e0 cu\u1ed1i c\u00f9ng th\u00e0nh kh\u00ed Nit\u01a1, tr\u1edf l\u1ea1i kh\u00ed quy\u1ec3n. Nitrit l\u00e0 trung gian trong c\u1ea3 hai qu\u00e1 tr\u00ecnh. \u0110\u1ec3 lo\u1ea1i b\u1ecf hi\u1ec7u qu\u1ea3 c\u1ea3 ba h\u1ee3p ch\u1ea5t, m\u1ed9t h\u1ed7n h\u1ee3p vi khu\u1ea9n c\u00f3 kh\u1ea3 n\u0103ng nitrat h\u00f3a v\u00e0 \/ ho\u1eb7c kh\u1eed nitrat l\u00e0 l\u1ee3i th\u1ebf <\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

H\u00ecnh\n1: Nitrat h\u00f3a v\u00e0 kh\u1eed nitrat b\u1eb1ng vi khu\u1ea9n.<\/em><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

H\u00ecnh\n2: X\u1eed l\u00fd h\u1ee3p ch\u1ea5t nit\u01a1 b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p trong \u1ed1ng nghi\u1ec7m. Trong ph\u00f2ng th\u00ed\nnghi\u1ec7m, c\u00e1c t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c nu\u00f4i c\u1ea5y \u1edf \u0111i\u1ec1u ki\u1ec7n y\u1ebfm kh\u00ed trong hai ng\u00e0y v\u1edbi s\u1ef1\nhi\u1ec7n di\u1ec7n c\u1ee7a n\u1ed3ng \u0111\u1ed9 Amoni, Nitrat ho\u1eb7c Nitrit cao.<\/em><\/p>\n\n\n\n

C\u00e1c h\u1ee3p ch\u1ea5t\nl\u01b0u hu\u1ef3nh nh\u01b0 Hi\u0111ro Sunfua l\u00e0 m\u1ed9t v\u1ea5n \u0111\u1ec1 kh\u00e1c. Hi\u0111ro Sunfua \u0111\u01b0\u1ee3c sinh ra trong\nqu\u00e1 tr\u00ecnh ph\u00e2n h\u1ee7y k\u1ef5 kh\u00ed c\u00e1c ch\u1ea5t h\u1eefu c\u01a1 \u1edf \u0111\u00e1y ao. Hi\u0111ro Sunfua can thi\u1ec7p v\u00e0o\nqu\u00e1 tr\u00ecnh h\u00f4 h\u1ea5p hi\u1ebfu kh\u00ed, d\u1eabn \u0111\u1ebfn t\u00ecnh tr\u1ea1ng \u0111\u1ed9ng v\u1eadt b\u1ecb ngh\u1eb9t th\u1edf. B\u00f9n\n\u0111en ch\u00ednh l\u00e0 d\u00e2u hi\u1ec7u \u0111\u1ec3 nh\u1eadn bi\u1ebft s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a Hi\u0111ro Sunfua, b\u1edfi\nkhi Hi\u0111ro Sunfua v\u00e0 s\u1eaft ph\u1ea3n \u1ee9ng t\u1ea1o th\u00e0nh s\u1eaft sunfua c\u00f3 m\u00e0u \u0111en.<\/p>\n\n\n\n

M\u1ed9t s\u1ed1 lo\u00e0i\nvi khu\u1ea9n ti\u00eau th\u1ee5 Hi\u0111ro Sunfua, \u0111\u1eb7c bi\u1ec7t l\u00e0 c\u00e1c ch\u1ee7ng Thiobacillus <\/em>v\u00e0 Paracoccus<\/em>. Ch\u1eb3ng h\u1ea1n, Thiobacillus<\/em>\nc\u00f3 th\u1ec3 \u0111\u1ed3ng th\u1eddi lo\u1ea1i b\u1ecf Nitrat v\u00e0 Hi\u0111ro Sunfua trong ph\u1ea3n \u1ee9ng kh\u1eed Nit\u01a1 –\nSunfat h\u00f3a, chuy\u1ec3n \u0111\u1ed5i c\u00e1c h\u1ee3p ch\u1ea5t th\u00e0nh ion Sunfat v\u00e0 kh\u00ed Nit\u01a1 kh\u00f4ng \u0111\u1ed9c h\u1ea1i.<\/p>\n\n\n\n

L\u1ee3i khu\u1ea9n v\u00e0 m\u1ea7m b\u1ec7nh<\/strong> <\/p>\n\n\n\n

\u0110\u1ed1i kh\u00e1ng m\u1ea7m b\u1ec7nh\nl\u00e0 t\u00ednh n\u0103ng thi\u1ebft y\u1ebfu c\u1ee7a l\u1ee3i khu\u1ea9n. Nh\u00ecn chung, s\u1ef1 \u0111\u1ed1i kh\u00e1ng \u0111\u1ea1t \u0111\u01b0\u1ee3c th\u00f4ng\nqua c\u1ea1nh tranh lo\u1ea1i tr\u1eeb, bao g\u1ed3m m\u1ed9t s\u1ed1 c\u01a1 ch\u1ebf: sinh ra ch\u1ea5t kh\u00e1ng khu\u1ea9n nh\u01b0\nBacteriocins, s\u1ea3n xu\u1ea5t c\u00e1c axit h\u1eefu c\u01a1 l\u00e0m gi\u1ea3m pH trong \u0111\u01b0\u1eddng ti\u00eau h\u00f3a c\u1ee7a \u0111\u1ed9ng\nv\u1eadt, nh\u1edd \u0111\u00f3 ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a m\u1ea7m b\u1ec7nh, c\u1ea1nh tranh ch\u1ed7 \u1edf v\u00e0 c\u00e1c\nch\u1ea5t dinh d\u01b0\u1ee1ng.<\/em><\/p>\n\n\n\n

G\u1ea7n \u0111\u00e2y, xu\u1ea5t\nhi\u1ec7n m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p m\u1edbi \u0111\u1ed1i kh\u00e1ng v\u1edbi m\u1ea7m b\u1ec7nh: Ph\u00e1 v\u1ee1 Quorum Sensing – m\u1ed9t\nc\u01a1 ch\u1ebf giao ti\u1ebfp gi\u1eefa c\u00e1c t\u1ebf b\u00e0o vi khu\u1ea9n.<\/p>\n\n\n\n

Quorum Sensing\n(QS) m\u00f4 t\u1ea3 s\u1ef1 \u0111i\u1ec1u h\u00f2a c\u00e1c bi\u1ec3u hi\u1ec7n gen theo m\u1eadt \u0111\u1ed9 vi khu\u1ea9n. QS \u0111\u01b0\u1ee3c th\u1ef1c\nhi\u1ec7n th\u00f4ng qua vi\u1ec7c li\u00ean t\u1ee5c t\u1ea1o ra c\u00e1c ph\u00e2n t\u1eed t\u00edn hi\u1ec7u nh\u1ecf l\u00e0m trung\ngian. Khi qu\u1ea7n th\u1ec3 vi khu\u1ea9n ph\u00e1t tri\u1ec3n, c\u00e1c ph\u00e2n t\u1eed t\u00edn hi\u1ec7u t\u00edch t\u1ee5, khi \u0111\u1ea1t \u0111\u1ebfn\nng\u01b0\u1ee1ng, g\u00e2y ra nh\u1eefng thay \u0111\u1ed5i trong bi\u1ec3u hi\u1ec7n gen.<\/p>\n\n\n\n

C\u01a1 ch\u1ebf n\u00e0y cho\nph\u00e9p c\u00e1c qu\u1ea7n th\u1ec3 vi khu\u1ea9n \u0111i\u1ec1u khi\u1ec3n c\u00e1c ho\u1ea1t \u0111\u1ed9ng theo nh\u00f3m, nh\u01b0 h\u00ecnh th\u00e0nh\nm\u00e0ng sinh h\u1ecdc, g\u00e2y b\u1ec7nh v\u00e0 s\u1ea3n xu\u1ea5t ch\u1ea5t kh\u00e1ng khu\u1ea9n v\u00e0 Exoenzyme (Enzyme\nngo\u1ea1i b\u00e0o). Nh\u1eefng qu\u00e1 tr\u00ecnh n\u00e0y \u0111\u1eb7t g\u00e1nh n\u1eb7ng trao \u0111\u1ed5i ch\u1ea5t l\u00ean c\u00e1c t\u1ebf b\u00e0o\nv\u00e0 ch\u1ec9 c\u00f3 gi\u00e1 tr\u1ecb khi t\u1ef7 l\u1ec7 th\u00e0nh c\u00f4ng \u0111\u1ee7 cao. X\u00e9t v\u1ec1 m\u1eb7t g\u00e2y b\u1ec7nh, ch\u1ec9 c\u00f3\nnh\u1eefng y\u1ebfu t\u1ed1 g\u00e2y b\u1ec7nh hi\u1ec7u qu\u1ea3 v\u00e0 k\u1ecbp th\u1eddi m\u1edbi \u0111\u1ea3m b\u1ea3o cho vi\u1ec7c l\u00e2y\nnhi\u1ec5m th\u00e0nh c\u00f4ng.<\/em><\/p>\n\n\n\n

C\u00e1c nh\u00e0 nghi\u00ean\nc\u1ee9u \u0111\u00e3 x\u00e1c \u0111\u1ecbnh v\u00e0 ph\u00e2n l\u1eadp c\u00e1c lo\u1ea1i ph\u00e2n t\u1eed t\u00edn hi\u1ec7u. C\u00e1c ph\u00e2n t\u1eed t\u00edn hi\u1ec7u ph\u1ed5\nbi\u1ebfn nh\u1ea5t l\u00e0 Homoneine Lactones (AHL) \u0111\u1ed1i v\u1edbi vi khu\u1ea9n gram \u00e2m v\u00e0 ph\u00e2n t\u1eed\nPeptide nh\u1ecf cho vi khu\u1ea9n gram d\u01b0\u01a1ng. C\u00e1c \u0111i\u1ec1u ch\u1ec9nh nh\u01b0 thay \u0111\u1ed5i chi\u1ec1u d\u00e0i c\u1ee7a\nchu\u1ed7i b\u00ean Carbon c\u1ee7a AHL t\u1ea1o ra \u0111\u1eb7c tr\u01b0ng c\u1ee7a lo\u00e0i. Kh\u00f4ng ph\u1ee5 thu\u1ed9c v\u00e0o ph\u00e2n\nlo\u1ea1i gram, nhi\u1ec1u lo\u00e0i ph\u1ea3n \u1ee9ng, ph\u00e1t hi\u1ec7n ho\u1eb7c t\u1ea1o ra ph\u00e2n t\u1eed t\u00edn hi\u1ec7u ph\u1ed5\nAI-2.<\/p>\n\n\n\n

C\u00e1c ch\u1ee7ng vi\nkhu\u1ea9n nh\u01b0 Vibrios <\/em>s\u1eed d\u1ee5ng c\u00e1c ph\u00e2n t\u1eed\nt\u00edn hi\u1ec7u d\u00e0nh ri\u00eang cho m\u1ed9t nh\u00f3m vi khu\u1ea9n c\u00f3 li\u00ean quan. T\u1ea5t c\u1ea3 c\u00e1c ph\u00e2n t\u1eed n\u00e0y\ncung c\u1ea5p th\u00f4ng tin v\u1ec1 m\u00f4i tr\u01b0\u1eddng, th\u00e0nh ph\u1ea7n lo\u00e0i, s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a c\u00e1c \u0111\u1ed1i th\u1ee7\nc\u1ea1nh tranh v\u1ec1 ch\u1ea5t dinh d\u01b0\u1ee1ng v\u00e0 t\u00ecnh tr\u1ea1ng trao \u0111\u1ed5i ch\u1ea5t c\u1ee7a c\u1ed9ng \u0111\u1ed3ng vi\nkhu\u1ea9n.<\/p>\n\n\n\n

M\u1ed9t h\u1ec7 th\u1ed1ng\nt\u00edn hi\u1ec7u AHL c\u01a1 b\u1ea3n bao g\u1ed3m m\u1ed9t synthase (m\u1ed9t lo\u1ea1i enzyme x\u00fac t\u00e1c cho li\u00ean\nk\u1ebft gi\u1eefa 2 ph\u00e2n t\u1eed) \u0111\u1ec3 s\u1ea3n xu\u1ea5t AHL v\u00e0 m\u1ed9t y\u1ebfu t\u1ed1 phi\u00ean m\u00e3 nh\u1eadn th\u1ee9c \u0111\u1ec3 ph\u00e1t\nhi\u1ec7n AHL (H\u00ecnh 3). Khi li\u00ean k\u1ebft v\u1edbi AHL, m\u00e1y d\u00f2 s\u1ebd k\u00edch ho\u1ea1t \/ h\u1ee7y k\u00edch ho\u1ea1t\ngen m\u1ee5c ti\u00eau. C\u00e1c h\u1ec7 th\u1ed1ng \u0111a k\u00eanh tinh vi h\u01a1n \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n \u1edf khu\u1ea9n Vibrios<\/em>. \u1ede \u0111\u00e2y, c\u00e1c t\u00edn hi\u1ec7u kh\u00e1c nhau\n\u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n b\u1edfi c\u00e1c th\u1ee5 th\u1ec3 nh\u1eadn th\u1ee9c c\u1ee7a ch\u00fang trong m\u00e0ng v\u00e0 m\u1ed9t t\u1ea7ng \u0111i\u1ec1u\nh\u00f2a k\u00edch ho\u1ea1t \/ h\u1ee7y k\u00edch ho\u1ea1t gen m\u1ee5c ti\u00eau. M\u1ed7i t\u00edn hi\u1ec7u c\u00f3 m\u1ed9t k\u00eanh ri\u00eang v\u00e0\nth\u00f4ng tin t\u1eeb m\u1ed7i k\u00eanh \u0111\u01b0\u1ee3c chuy\u1ec3n \u0111\u1ed5i th\u00e0nh t\u1ea7ng t\u00edn hi\u1ec7u gi\u1ed1ng nhau.<\/p>\n\n\n\n

H\u00ecnh\n3: C\u01a1 ch\u1ebf Quorum Sensing c\u01a1 b\u1ea3n \u1edf vi khu\u1ea9n gram \u00e2m. C\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng \u00e1p d\u1ee5ng\nQuorum queching \u0111\u01b0\u1ee3c d\u00e1n sao \u0111en.<\/em><\/p>\n\n\n\n

Quorum quenching – \u1ee8c ch\u1ebf giao ti\u1ebfp \u1edf vi khu\u1ea9n<\/strong><\/p>\n\n\n\n

Khi giao ti\u1ebfp b\u1ecb ph\u00e1 v\u1ee1, c\u00e1c ho\u1ea1t \u0111\u1ed9ng nh\u00f3m kh\u00f4ng th\u1ec3 \u0111\u01b0\u1ee3c ph\u1ed1i h\u1ee3p v\u00e0 nh\u1eefng \u0111\u1eb7c tr\u01b0ng do QS quy \u0111\u1ecbnh c\u0169ng kh\u00f4ng ho\u1ea1t \u0111\u1ed9ng. Trong tr\u01b0\u1eddng h\u1ee3p t\u1ed1t nh\u1ea5t, vi\u1ec7c \u201cc\u1eaft li\u00ean l\u1ea1c\u201d l\u00e0m cho vi khu\u1ea9n b\u1edbt \u0111\u1ed9c t\u00ednh v\u00e0 d\u1ec5 b\u1ecb t\u1ed5n th\u01b0\u01a1ng h\u01a1n.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Quorum quenching nh\u1eafm v\u00e0o m\u1ed9t s\u1ed1 b\u01b0\u1edbc trong h\u1ec7 th\u1ed1ng QS (H\u00ecnh 3). Khi vi\u1ec7c t\u1ed5ng h\u1ee3p c\u00e1c ph\u00e2n t\u1eed t\u00edn hi\u1ec7u b\u1ecb \u1ee9c ch\u1ebf, c\u00e1c t\u1ebf b\u00e0o s\u1ebd kh\u00f4ng th\u1ec3 giao ti\u1ebfp. N\u1ebfu m\u1ee5c ti\u00eau l\u00e0 ph\u00e1t hi\u1ec7n t\u00edn hi\u1ec7u, t\u00ednh \u1ed5n \u0111\u1ecbnh c\u1ee7a th\u1ee5 th\u1ec3 b\u1ecb \u1ea3nh h\u01b0\u1edfng ho\u1eb7c c\u00e1c ph\u00e2n t\u1eed t\u01b0\u01a1ng t\u1ef1 v\u1ec1 m\u1eb7t c\u1ea5u tr\u00fac ch\u1eb7n truy c\u1eadp v\u00e0o v\u1ecb tr\u00ed g\u1eafn k\u1ebft th\u1ee5 th\u1ec3, nh\u01b0ng kh\u00f4ng k\u00edch ho\u1ea1t th\u1ee5 th\u1ec3. C\u00e1c ph\u00e2n t\u1eed t\u00edn hi\u1ec7u c\u00f3 th\u1ec3 b\u1ecb ph\u00e1 h\u1ee7y b\u1edfi s\u1ef1 suy gi\u1ea3m enzyme v\u00e0 do \u0111\u00f3, c\u00e1c th\u00f4ng \u0111i\u1ec7p kh\u00f4ng bao gi\u1edd \u0111\u1ebfn \u0111\u01b0\u1ee3c c\u00e1c vi khu\u1ea9n ti\u1ebfp nh\u1eadn <\/p>\n\n\n\n

Nhi\u1ec1u ch\u1ea5t \u1ee9c\nch\u1ebf trong t\u1ef1 nhi\u00ean \u0111\u01b0\u1ee3c sinh ra b\u1edfi th\u1ef1c v\u1eadt, vi khu\u1ea9n v\u00e0 t\u1ea3o. Ch\u1eb3ng h\u1ea1n, t\u1ecfi\nc\u00f3 ch\u1ee9a c\u00e1c h\u1ee3p ch\u1ea5t ng\u0103n ch\u1eb7n d\u00f2ng th\u00f4ng tin v\u00e0 t\u1ea3o \u0111\u1ecf Delisea pulchra <\/em>t\u1ea1o ra c\u00e1c halogenated furanones<\/em> m\u00f4 ph\u1ecfng c\u00e1c ph\u00e2n t\u1eed t\u00edn hi\u1ec7u v\u00e0 ng\u0103n ch\u1eb7n ch\u00fang ti\u1ebfp c\u1eadn\nv\u1edbi th\u1ee5 th\u1ec3.<\/p>\n\n\n\n

Vi khu\u1ea9n \u0111\u00e3\nph\u00e1t tri\u1ec3n c\u00e1c c\u01a1 ch\u1ebf \u0111\u1ec3 ti\u00eau di\u1ec7t v\u00e0 l\u00e0m suy gi\u1ea3m AHL. M\u1ed9t s\u1ed1 lo\u00e0i Bacillus s\u1ea3n\nxu\u1ea5t enzyme th\u1ee7y ph\u00e2n v\u00f2ng lacton c\u1ee7a AHL. C\u00e1c lo\u00e0i kh\u00e1c, nh\u01b0 Ralstonia <\/em>ho\u1eb7c Variovorax<\/em>, t\u1ea1o ra c\u00e1c enzyme nh\u1eafm v\u00e0o c\u00e1c li\u00ean k\u1ebft amide c\u1ee7a AHL.\nVi khu\u1ea9n c\u00f3 l\u1ee3i kh\u00f4ng ch\u1ec9 \u0111\u00e1nh v\u00e0o s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a m\u1ea7m b\u1ec7nh, m\u00e0 s\u1edf h\u1eefu c\u00e1c\nenzyme n\u00e0y c\u00f3 th\u1ec3 ki\u1ec3m so\u00e1t m\u1ea7m b\u1ec7nh theo hai c\u00e1ch. T\u0103ng tr\u01b0\u1edfng b\u1ecb \u1ee9c ch\u1ebf tr\u1ef1c\nti\u1ebfp b\u1edfi vi\u1ec7c s\u1ea3n xu\u1ea5t c\u00e1c ch\u1ea5t kh\u00e1ng khu\u1ea9n. S\u1ef1 li\u00ean l\u1ea1c gi\u1eefa c\u00e1c t\u1ebf\nb\u00e0o m\u1ea7m b\u1ec7nh c\u0169ng b\u1ecb ph\u00e1 v\u1ee1 \u0111\u1ec3 l\u00e0m gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng c\u1ee7a ch\u00fang.<\/p>\n\n\n\n

C\u00e1c h\u1ec7 th\u1ed1ng Quenching<\/strong><\/p>\n\n\n\n

Trong v\u00e0i th\u1eadp k\u1ef7 qua, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t tri\u1ec3n r\u1ea5t nhi\u1ec1u ch\u1ee7ng ch\u1ec9 th\u1ecb v\u1edbi c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m nh\u01b0 ph\u00e1t s\u00e1ng, ph\u00e1t hu\u1ef3nh quang ho\u1eb7c s\u1ea3n xu\u1ea5t s\u1eafc t\u1ed1 khi c\u00f3 m\u1eb7t c\u00e1c ph\u00e2n t\u1eed t\u00edn hi\u1ec7u QS. Nh\u1eefng ch\u1ee7ng ch\u1ec9 th\u1ecb n\u00e0y \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ph\u00e1t hi\u1ec7n nh\u01b0ng c\u0169ng \u0111\u1ec3 ki\u1ec3m tra vi\u1ec7c c\u1eaft li\u00ean l\u1ea1c gi\u1eefa c\u00e1c vi khu\u1ea9n. Do l\u1ee3i khu\u1ea9n s\u1ea3n sinh ra c\u00e1c ch\u1ea5t kh\u00e1ng khu\u1ea9n, \u0111i\u1ec1u quan tr\u1ecdng l\u00e0 ph\u1ea3i x\u00e1c \u0111\u1ecbnh c\u1ea9n th\u1eadn li\u1ec7u t\u00e1c d\u1ee5ng c\u1ee7a vi\u1ec7c \u201cc\u1eaft li\u00ean l\u1ea1c” c\u00f3 hi\u00ea\u1ee5 qu\u1ea3 d\u1ef1a tr\u00ean vi\u1ec7c thi\u1ebfu giao ti\u1ebfp c\u1ee7a vi khu\u1ea9n hay do c\u00e1c ch\u1ea5t kh\u00e1ng khu\u1ea9n. (H\u00ecnh 4)<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

H\u00ecnh 4: V\u00ed d\u1ee5 Quorum quenching. \u1ee8c ch\u1ebf t\u0103ng tr\u01b0\u1edfng theo m\u1eb7c \u0111\u1ecbnh d\u1eabn \u0111\u1ebfn ho\u1ea1t \u0111\u1ed9ng \u00edt li\u00ean quan \u0111\u1ebfn QS (ph\u00e1t s\u00e1ng).<\/p>\n\n\n\n

Ngu\u1ed3n : aquacultureallianc<\/a><\/p>\n\n\n\n

D\u1ecbch: BIOTEK TEAM<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Vi khu\u1ea9n g\u00e2y b\u1ec7nh ch\u00ednh l\u00e0 m\u1ed1i quan t\u00e2m ch\u00ednh trong ng\u00e0nh nu\u00f4i tr\u1ed3ng th\u1ee7y s\u1ea3n<\/p>\n","protected":false},"author":4,"featured_media":7924,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[2,5],"tags":[32,36,34,33,35],"class_list":["post-7923","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sinh-hoc","category-thuy-san","tag-men-vi-sinh","tag-probiotic","tag-sinh-hoc","tag-uc-che-vi-khuan-gay-hai","tag-vibrio"],"yoast_head":"\nVi khu\u1ea9n c\u00f3 l\u1ee3i v\u00e0 ki\u1ec3m so\u00e1t m\u1ea7m b\u1ec7nh - H\u1ea3i H\u01b0ng Probiotics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hhbio.vn\/?p=7923\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vi khu\u1ea9n c\u00f3 l\u1ee3i v\u00e0 ki\u1ec3m so\u00e1t m\u1ea7m b\u1ec7nh\" \/>\n<meta property=\"og:description\" content=\"Vi khu\u1ea9n g\u00e2y b\u1ec7nh ch\u00ednh l\u00e0 m\u1ed1i quan t\u00e2m ch\u00ednh trong ng\u00e0nh nu\u00f4i tr\u1ed3ng th\u1ee7y s\u1ea3n\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hhbio.vn\/?p=7923\" \/>\n<meta property=\"og:site_name\" content=\"H\u1ea3i H\u01b0ng Probiotics\" \/>\n<meta property=\"article:published_time\" content=\"2019-02-25T08:17:22+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-06-25T15:09:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/WEBERpic1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"960\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"16 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/hhbio.vn\/?p=7923#article\",\"isPartOf\":{\"@id\":\"https:\/\/hhbio.vn\/?p=7923\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/hhbio.vn\/#\/schema\/person\/39485024c55ecf320ea3302bad2b6ef4\"},\"headline\":\"Vi khu\u1ea9n c\u00f3 l\u1ee3i v\u00e0 ki\u1ec3m so\u00e1t m\u1ea7m b\u1ec7nh\",\"datePublished\":\"2019-02-25T08:17:22+00:00\",\"dateModified\":\"2019-06-25T15:09:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/hhbio.vn\/?p=7923\"},\"wordCount\":3142,\"publisher\":{\"@id\":\"https:\/\/hhbio.vn\/#organization\"},\"image\":{\"@id\":\"https:\/\/hhbio.vn\/?p=7923#primaryimage\"},\"thumbnailUrl\":\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/WEBERpic1.jpg\",\"keywords\":[\"men vi sinh\",\"probiotic\",\"sinh h\u1ecdc\",\"\u1ee9c ch\u1ebf vi khu\u1ea9n g\u00e2y h\u1ea1i\",\"vibrio\"],\"articleSection\":[\"Sinh h\u1ecdc\",\"Th\u1ee7y s\u1ea3n\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/hhbio.vn\/?p=7923\",\"url\":\"https:\/\/hhbio.vn\/?p=7923\",\"name\":\"Vi khu\u1ea9n c\u00f3 l\u1ee3i v\u00e0 ki\u1ec3m so\u00e1t m\u1ea7m b\u1ec7nh - H\u1ea3i H\u01b0ng Probiotics\",\"isPartOf\":{\"@id\":\"https:\/\/hhbio.vn\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/hhbio.vn\/?p=7923#primaryimage\"},\"image\":{\"@id\":\"https:\/\/hhbio.vn\/?p=7923#primaryimage\"},\"thumbnailUrl\":\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/WEBERpic1.jpg\",\"datePublished\":\"2019-02-25T08:17:22+00:00\",\"dateModified\":\"2019-06-25T15:09:49+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/hhbio.vn\/?p=7923#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/hhbio.vn\/?p=7923\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/hhbio.vn\/?p=7923#primaryimage\",\"url\":\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/WEBERpic1.jpg\",\"contentUrl\":\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/WEBERpic1.jpg\",\"width\":960,\"height\":720},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/hhbio.vn\/?p=7923#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/hhbio.vn\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Vi khu\u1ea9n c\u00f3 l\u1ee3i v\u00e0 ki\u1ec3m so\u00e1t m\u1ea7m b\u1ec7nh\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/hhbio.vn\/#website\",\"url\":\"https:\/\/hhbio.vn\/\",\"name\":\"BIOTEKCO\",\"description\":\"Building Products For You\",\"publisher\":{\"@id\":\"https:\/\/hhbio.vn\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/hhbio.vn\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/hhbio.vn\/#organization\",\"name\":\"BIOTEKCO.,LTD\",\"url\":\"https:\/\/hhbio.vn\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/hhbio.vn\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/01\/logo-cmyk-01-1-e1560779045791.png\",\"contentUrl\":\"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/01\/logo-cmyk-01-1-e1560779045791.png\",\"width\":216,\"height\":90,\"caption\":\"BIOTEKCO.,LTD\"},\"image\":{\"@id\":\"https:\/\/hhbio.vn\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/hhbio.vn\/#\/schema\/person\/39485024c55ecf320ea3302bad2b6ef4\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/hhbio.vn\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/60ff287c3f4ad60471147e6035b7a6ab4e48cf6d5733f6bc839ca2a2caee08df?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/60ff287c3f4ad60471147e6035b7a6ab4e48cf6d5733f6bc839ca2a2caee08df?s=96&d=mm&r=g\",\"caption\":\"admin\"}}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Vi khu\u1ea9n c\u00f3 l\u1ee3i v\u00e0 ki\u1ec3m so\u00e1t m\u1ea7m b\u1ec7nh - H\u1ea3i H\u01b0ng Probiotics","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/hhbio.vn\/?p=7923","og_locale":"en_US","og_type":"article","og_title":"Vi khu\u1ea9n c\u00f3 l\u1ee3i v\u00e0 ki\u1ec3m so\u00e1t m\u1ea7m b\u1ec7nh","og_description":"Vi khu\u1ea9n g\u00e2y b\u1ec7nh ch\u00ednh l\u00e0 m\u1ed1i quan t\u00e2m ch\u00ednh trong ng\u00e0nh nu\u00f4i tr\u1ed3ng th\u1ee7y s\u1ea3n","og_url":"https:\/\/hhbio.vn\/?p=7923","og_site_name":"H\u1ea3i H\u01b0ng Probiotics","article_published_time":"2019-02-25T08:17:22+00:00","article_modified_time":"2019-06-25T15:09:49+00:00","og_image":[{"width":960,"height":720,"url":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/WEBERpic1.jpg","type":"image\/jpeg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Written by":"admin","Est. reading time":"16 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/hhbio.vn\/?p=7923#article","isPartOf":{"@id":"https:\/\/hhbio.vn\/?p=7923"},"author":{"name":"admin","@id":"https:\/\/hhbio.vn\/#\/schema\/person\/39485024c55ecf320ea3302bad2b6ef4"},"headline":"Vi khu\u1ea9n c\u00f3 l\u1ee3i v\u00e0 ki\u1ec3m so\u00e1t m\u1ea7m b\u1ec7nh","datePublished":"2019-02-25T08:17:22+00:00","dateModified":"2019-06-25T15:09:49+00:00","mainEntityOfPage":{"@id":"https:\/\/hhbio.vn\/?p=7923"},"wordCount":3142,"publisher":{"@id":"https:\/\/hhbio.vn\/#organization"},"image":{"@id":"https:\/\/hhbio.vn\/?p=7923#primaryimage"},"thumbnailUrl":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/WEBERpic1.jpg","keywords":["men vi sinh","probiotic","sinh h\u1ecdc","\u1ee9c ch\u1ebf vi khu\u1ea9n g\u00e2y h\u1ea1i","vibrio"],"articleSection":["Sinh h\u1ecdc","Th\u1ee7y s\u1ea3n"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/hhbio.vn\/?p=7923","url":"https:\/\/hhbio.vn\/?p=7923","name":"Vi khu\u1ea9n c\u00f3 l\u1ee3i v\u00e0 ki\u1ec3m so\u00e1t m\u1ea7m b\u1ec7nh - H\u1ea3i H\u01b0ng Probiotics","isPartOf":{"@id":"https:\/\/hhbio.vn\/#website"},"primaryImageOfPage":{"@id":"https:\/\/hhbio.vn\/?p=7923#primaryimage"},"image":{"@id":"https:\/\/hhbio.vn\/?p=7923#primaryimage"},"thumbnailUrl":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/WEBERpic1.jpg","datePublished":"2019-02-25T08:17:22+00:00","dateModified":"2019-06-25T15:09:49+00:00","breadcrumb":{"@id":"https:\/\/hhbio.vn\/?p=7923#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/hhbio.vn\/?p=7923"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/hhbio.vn\/?p=7923#primaryimage","url":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/WEBERpic1.jpg","contentUrl":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/02\/WEBERpic1.jpg","width":960,"height":720},{"@type":"BreadcrumbList","@id":"https:\/\/hhbio.vn\/?p=7923#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/hhbio.vn\/"},{"@type":"ListItem","position":2,"name":"Vi khu\u1ea9n c\u00f3 l\u1ee3i v\u00e0 ki\u1ec3m so\u00e1t m\u1ea7m b\u1ec7nh"}]},{"@type":"WebSite","@id":"https:\/\/hhbio.vn\/#website","url":"https:\/\/hhbio.vn\/","name":"BIOTEKCO","description":"Building Products For You","publisher":{"@id":"https:\/\/hhbio.vn\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/hhbio.vn\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/hhbio.vn\/#organization","name":"BIOTEKCO.,LTD","url":"https:\/\/hhbio.vn\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/hhbio.vn\/#\/schema\/logo\/image\/","url":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/01\/logo-cmyk-01-1-e1560779045791.png","contentUrl":"https:\/\/hhbio.vn\/wp-content\/uploads\/2019\/01\/logo-cmyk-01-1-e1560779045791.png","width":216,"height":90,"caption":"BIOTEKCO.,LTD"},"image":{"@id":"https:\/\/hhbio.vn\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/hhbio.vn\/#\/schema\/person\/39485024c55ecf320ea3302bad2b6ef4","name":"admin","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/hhbio.vn\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/60ff287c3f4ad60471147e6035b7a6ab4e48cf6d5733f6bc839ca2a2caee08df?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/60ff287c3f4ad60471147e6035b7a6ab4e48cf6d5733f6bc839ca2a2caee08df?s=96&d=mm&r=g","caption":"admin"}}]}},"_links":{"self":[{"href":"https:\/\/hhbio.vn\/index.php?rest_route=\/wp\/v2\/posts\/7923","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hhbio.vn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hhbio.vn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hhbio.vn\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/hhbio.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7923"}],"version-history":[{"count":1,"href":"https:\/\/hhbio.vn\/index.php?rest_route=\/wp\/v2\/posts\/7923\/revisions"}],"predecessor-version":[{"id":8455,"href":"https:\/\/hhbio.vn\/index.php?rest_route=\/wp\/v2\/posts\/7923\/revisions\/8455"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/hhbio.vn\/index.php?rest_route=\/wp\/v2\/media\/7924"}],"wp:attachment":[{"href":"https:\/\/hhbio.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7923"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hhbio.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7923"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hhbio.vn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7923"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}